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lycorenine

from Lycoris radiata Herb. (Liliaceae); has vasodepressor effect; RN from 9th CI; RN given refers to (7alpha)-isomer

Also Known As:

(7 alpha)-9,10-dimethoxy-1-methyllycorenan-7-ol

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Amaryllidaceae Alkaloids: 33
        lycorenine: 3
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Amaryllidaceae Alkaloids: 33
    - lycorenine: 3

Experts

1.	Shawky, Eman: 1 article (11/2017)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 08/01/1979 - "Lycorenine (more than 1 mg/kg i.v.) blocked the pressor response to sympathetic nerve stimulation, but failed to block the tachycardia induced by sympathetic nerve stimulation. "
2.	Human Influenza (Influenza) 11/01/2017 - "As expected, galanthamine-type alkaloids were the most active against hACHE; yet, lycorenine- and tazettine-type alkaloids contributed significantly, while lycorine-type alkaloids dominated the hit list against HIV-1 PR target protein and were significantly active against HIV-1 RT and influenza NA. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/01/1995 - "On the other hand, lycorenine (11) was found to be the most cytotoxic compound against HepG2 hepatoma, even though it appears to be active against Molt4 cells. "
4.	Bradycardia 08/01/1979 - "The maximal bradycardia induced by lycorenine was abolished by bilateral vagotomy. " 08/01/1979 - "It is suggested that lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity."

Related Drugs and Biologics

1.	Adrenergic Agents (Adrenergic Drugs)
2.	Proteins (Proteins, Gene)
3.	Galantamine (Galanthamine)
4.	Alkaloids
5.	lycorine
6.	tazettine

Related Therapies and Procedures

1.	Vagotomy