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5-(aminomethyl)-2'-deoxyuridine
structure given in first source
Also Known As:
5'-aminothymidine; alpha-aminothymidine
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Thymidine: 4460
5-(aminomethyl)-2'-deoxyuridine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Thymidine: 4460
5-(aminomethyl)-2'-deoxyuridine: 3
Deoxyribonucleosides: 34
Thymidine: 4460
5-(aminomethyl)-2'-deoxyuridine: 3
Related Diseases
1.
Urinary Bladder Neoplasms (Bladder Cancer)
09/01/1986 - "
in this study the phosphorylation, uptake, and cytotoxicity of iododeoxyuridine was markedly enhanced by 5'-aminothymidine in three human bladder cancer cell lines, T24, HT1197 and 647V.
"
09/01/1986 - "
Preferential stimulation of iododeoxyuridine phosphorylation by 5'-aminothymidine in human bladder cancer cells in vitro.
"
05/01/1989 - "
We have previously reported that 5'-aminothymidine (5'-AdThd), an antagonist of the feedback inhibition exerted by dTTP that regulates thymidine kinase, enhances the uptake and cytotoxicity of 5-iododeoxyuridine in various human bladder cancer cell lines but not in normal human urothelial cells (HU) propagated in vitro.
"
2.
Colonic Neoplasms (Colon Cancer)
04/01/1995 - "
Effects of 5'-aminothymidine and leucovorin on radiosensitization by iododeoxyuridine in human colon cancer cells
"
04/01/1995 - "
We examined the effects of two biochemical modulators, 5'-aminothymidine (5'-AdThd) and leucovorin (LV), on the in vitro incorporation of iododeoxyuridine (IdUrd) into DNA and its subsequent radiosensitization in two human colon cancer cell lines, HT 29 and HCT 116.
"
Related Drugs and Biologics
1.
Idoxuridine (Stoxil)
2.
Thymidine Kinase
3.
DNA (Deoxyribonucleic Acid)
4.
Leucovorin (Folinic Acid)
5.
thymidine 5'-triphosphate (thymidine triphosphate)