HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

WR 149024

Also Known As:

WR 149,024; WR-149,024; WR-149024; 1,18-diamino-7,13-diaza-9,10-dithiaoctadecane tetrahydrochloride

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - WR 149024: 4

Related Diseases

1.	Exsanguination 08/01/1985 - "WR 149024 (either 5.0 or 50.0 mg/kg) was administered intraperitoneally (i.p.) to conscious rats during exsanguination. "
2.	Hemorrhagic Shock 11/01/1973 - "The treatment of hemorrhagic shock with WR-149,024 (1,18-diamino-6,13-diaza-9,10-dithiaoctadecane tetrahydrochloride)."
3.	Hypotension (Low Blood Pressure) 12/01/1972 - "1. The general cardiovascular properties of WR-149,024 (a straight chain sulphur-containing aliphatic amine) in dogs and cats are reported.2. Intravenous administration of this compound produced an immediate hypotension and bradycardia in intact anaesthetized dogs. " 12/01/1972 - "It appears that the initial hypotension is due to a decrease in total peripheral vascular resistance since WR-149,024 produced relatively little change in force of contraction or heart rate in the isolated, blood-perfused heart preparation.4. WR-149,024 reversed the pressor effects of adrenaline within 10 min of injection while at the same time the vasopressor response to angiotensin or the vasodepressor response to isoprenaline was not altered. "
4.	Hemorrhage 08/01/1985 - "The effect of WR 149024 on survival following hemorrhage in conscious rats." 08/01/1985 - "The effect of WR 149024, an alpha-receptor antagonist, on survival following hemorrhage with no volume replacement therapy, was investigated. "
5.	Bradycardia 12/01/1972 - "1. The general cardiovascular properties of WR-149,024 (a straight chain sulphur-containing aliphatic amine) in dogs and cats are reported.2. Intravenous administration of this compound produced an immediate hypotension and bradycardia in intact anaesthetized dogs. "

Related Drugs and Biologics

1.	Isoproterenol (Isoprenaline)
2.	Epinephrine (Adrenaline)
3.	Angiotensins
4.	Amines

Related Therapies and Procedures

1.	Intravenous Administration
2.	Therapeutics