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chloroquine diphosphate

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RN given refers to diphosphate[1:2] cpd without isomeric designation

Also Known As:

Resochin; arechin; chingamin phosphate; chloroquine bis(dihydrogenphosphate) dihydrate; chloroquine diphosphate, (+)-isomer; chloroquine diphosphate, (+-)-isomer; chloroquine diphosphate, (-)-isomer; chloroquine phosphate; delagil; khingamin phosphate; unspecified phosphate of chloroquine diphosphate; N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine, phosphate (1:2)

Networked: 241 relevant articles (10 outcomes, 15 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinolines: 92
    - Aminoquinolines: 11
      - Chloroquine: 4887
        chloroquine diphosphate: 241

Experts

1.	Borba, E F: 3 articles (01/2007 - 04/2001)
2.	Bonfá, E: 3 articles (01/2007 - 04/2001)
3.	Shinjo, Samuel Katsuyuki: 2 articles (05/2013 - 05/2009)
4.	Sysa-Jedrzejowska, A: 2 articles (05/2010 - 01/2006)
5.	Gao, Menghua: 1 article (01/2015)
6.	Xu, Yuzhen: 1 article (01/2015)
7.	Qiu, Liyan: 1 article (01/2015)
8.	Navarro, Maribel: 1 article (01/2014)
9.	Castro, William: 1 article (01/2014)
10.	Amalvict, Rémy: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2010 - "Chloroquine diphosphate (25mg/kg and 50mg/kg, respectively) significantly inhibited the growth of the implanted 4T1 tumor cells and induced apoptosis in the tumor microenvironment. " 01/01/1978 - "Under study was the efficacy of intrapleural injection of delagil in 28 patients with pulmonary cancer, breast cancer and other malignant tumors with the presence of exudate in the pleural cavities. " 01/01/1978 - "In highly sensitive tumors (cancer of ovaries, breast cancer) the treatment should be initiated with intrapleural injection of thiophosphamide or embichine, and in case of failure delagil is to be employed intrapleurally. " 01/01/1973 - "Inhibiting effect of chloroquine diphosphate on the growth of tumors and activity of some acid hydrolases of a melanotic melanoma in golden hamsters (Mesocricetus auratus, Waterhouse)." 10/01/1988 - "Based on previous studies done on retrovirus caused mouse mammary adenocarcinoma, it is suggested that a treatment regimen with 6-propylthiouracil, chloroquine phosphate and 5-fluorouracil (which resulted in 77% and 65% complete mouse tumor remission), may be effective in treating AIDS and other retrovirus-caused diseases."
2.	Malaria 05/01/1952 - "Malaria treated successfully with resochin." 10/01/2004 - "The paper presents the results of a study of immunological parameters in the indigenous adult population of an endemic area of Guinea in tropical malaria of varying severity and the time course of changes in these parameters in different phases of the disease during delagil treatment. " 01/01/2014 - "When chloroquine diphosphate (CQDP) lost its efficiency as a first-line anti-malarial drug, this was a major setback in the effective control of malaria. " 10/01/2013 - "Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice. " 08/01/2013 - "We report the case of a 54-year-old man who was admitted with an approximately 10-hour history of muscle twitching around the eyes, face and neck after he took the first dose of oral chloroquine phosphate (1 g [600 mg base]) prescribed for uncomplicated malaria. "
3.	Breast Neoplasms (Breast Cancer) 11/01/2010 - "In vitro treatment of 4T1 mouse breast cancer cells with chloroquine diphosphate resulted in significant inhibition of cellular proliferation and viability, and induction of apoptosis in 4T1 cells in a time- and dose-dependent manner. " 11/01/2010 - "Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer." 11/01/2010 - "These data suggested that chloroquine diphosphate might have chemotherapeutic efficacy against breast cancer including inhibition of metastasis." 01/01/1978 - "Under study was the efficacy of intrapleural injection of delagil in 28 patients with pulmonary cancer, breast cancer and other malignant tumors with the presence of exudate in the pleural cavities. " 01/01/1978 - "In highly sensitive tumors (cancer of ovaries, breast cancer) the treatment should be initiated with intrapleural injection of thiophosphamide or embichine, and in case of failure delagil is to be employed intrapleurally. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/1996 - "Controlled trial with chloroquine diphosphate in systemic lupus erythematosus." 05/01/2009 - "[Diagnostic methods for chloroquine diphosphate induced retinopathy in systemic lupus erythematosus]." 01/01/2006 - "The cardiac safety of chloroquine phosphate treatment in patients with systemic lupus erythematosus: the influence on arrhythmia, heart rate variability and repolarization parameters." 10/01/1987 - "Biventricular hypertrophy and failure developed in two patients during treatment of systemic lupus erythematosus with chloroquine phosphate. " 05/01/2010 - "Effect of chloroquine phosphate treatment on serum MMP-9 and TIMP-1 levels in patients with systemic lupus erythematosus."
5.	Lung Neoplasms (Lung Cancer) 05/01/2006 - "To investigate the effects of chloroquine diphosphate (CQ) on lung cancer cell growth, we treated A549 cells, a lung cancer cell line, with the drug at various concentrations (0.25-128 microM) for 24-72 h. " 01/01/1978 - "Under study was the efficacy of intrapleural injection of delagil in 28 patients with pulmonary cancer, breast cancer and other malignant tumors with the presence of exudate in the pleural cavities. "

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Pyrimethamine (Daraprim)
3.	Sulfadoxine (Sulformethoxine)
4.	Fluorouracil (Carac)
5.	Proguanil (Paludrine)
6.	sulfadoxine-pyrimethamine (Fansidar)
7.	Cytidine Diphosphate (CDP)
8.	alpha-Tocopherol
9.	Protective Agents
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Chemoprevention
3.	Aftercare (After-Treatment)
4.	Renal Dialysis (Hemodialysis)
5.	Castration