pregna-4,17-diene-3,16-dione (guggulsterone)

12/01/2006 - "Administration of guggulsterone significantly reduced the severity of DSS-induced murine colitis as assessed by clinical disease activity score, colon length, and histology. "
01/01/2018 - "Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages."
07/01/2010 - "This study investigates the anti-inflammatory effects of novel guggulsterone derivatives on IEC and preventive and therapeutic murine models of DSS-induced colitis. "
01/01/2018 - "We focused here on the effects of guggulsterone on macrophage modulation in colitis as a potential therapeutic molecule in human IBD and explore the underlying mechanisms. "
12/01/2006 - "Therefore, we investigated anti-inflammatory effects of guggulsterone on intestinal epithelial cells (IEC) and on experimental murine colitis models and elucidated its molecular mechanisms. "

12/01/2006 - "It remains unknown, however, whether guggulsterone is effective for the treatment of inflammatory bowel disease (IBD). "
07/01/2022 - "The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence."
06/13/2013 - "These results indicate that the novel guggulsterone derivative GG-52 blocks NF-κB activation in BMDCs and ameliorates chronic colitis in IL-10(-/-) mice, which suggest that GG-52 is a potential therapeutic agent for inflammatory bowel diseases."
07/01/2010 - "These results indicate that the novel guggulsterone derivative GG-52 blocks NF-kappaB activation in IEC and ameliorates DSS-induced acute murine colitis, which suggests that GG-52 is a potential therapeutic agent for the treatment of inflammatory bowel diseases."
01/01/2018 - "Overall, these data support that guggulsterone as a natural plant sterol modulates macrophage phenotypes in colitis, which may be of novel therapeutic importance in inflammatory bowel disease treatment."

10/01/2012 - "Guggulsterone is a dietary plant sterone possessing therapeutic potential against cancers. "
01/01/2023 - "Conclusion: This study suggested that Guggulsterone has apoptotic effects against various cancer types. "
04/01/2021 - "Z-guggulsterone (Z-GS), an active compound extracted from the gumresin of the Commiphora mukul tree, has been shown to have anti-tumor effects in NSCLC in our previous study. "
11/05/2012 - "The present study is to further investigate the reversal effects of guggulsterone on MDR in drug-resistant cancer cell lines. "
11/01/2008 - "This review describes the identification of molecular targets of guggulsterone, cellular responses to guggulsterone, and animal studies and clinical trials of guggulsterone in cancer and other diseases."

01/01/2008 - "Together, our results provide compelling rationale for further preclinical and clinical investigation of z-guggulsterone for its efficacy against prostate cancer."
01/01/2008 - "Our previous studies have shown that z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. "
11/01/2005 - "The present study was undertaken to gain insights into the molecular mechanism of cell death (apoptosis) by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, using PC-3 human prostate cancer cells as a model. "
01/01/2008 - "The z-guggulsterone treatment inhibited capillary-like tube formation (in vitro neovascularization) by human umbilical vein endothelial cells (HUVEC) and migration by HUVEC and DU145 human prostate cancer cells in a concentration- and time-dependent manner. "
08/01/2007 - "The guggulsterone treatment caused generation of ROI in prostate cancer cells but not in a normal prostate epithelial cell line (PrEC), which was also resistant to guggulsterone-mediated JNK activation. "

06/28/2009 - "This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. "
12/01/2008 - "We investigated the anti-tumor effects of guggulsterone on colon cancer cells and elucidated the underlying molecular mechanisms related to angiogenesis. "
12/01/2008 - "Guggulsterone significantly reduced cell viability in colon cancer cells in a dose-dependent manner and blocked VEGF, ARNT and STAT3 expression prominently in hypoxic conditions. "
12/01/2008 - "Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells."
06/28/2009 - "Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts."