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lactosylsphingosine

RN from 9th CI, Form Index; RN given refers to (E)-isomer

Also Known As:

2-amino-3-hydroxy-4-octadecenyl 4-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside (E)

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 07/01/1980 - "Occurrence of lactosylsphingosine-reactive antibodies in sera of cancer patients." 10/01/1979 - "[Possibility of using antibodies to lactosylsphingosine in the diagnosis of neoplasms]."
2.	GM1 Gangliosidosis (Gangliosidosis GM1) 08/15/1987 - "Lactosylsphingosine beta-galactosidase activities assayed in the absence and the presence of taurocholate (probably lactosylceramidase I) were deficient in fibroblasts from patients with globoid cell leukodystrophy, while the activity assayed with sodium cholate (probably lactosylceramidase II) was deficient in GM1 gangliosidosis fibroblasts. "
3.	Colorectal Neoplasms (Colorectal Cancer) 07/01/1982 - "The sera of 71 patients with colorectal cancer were examined for lactosylsphingosine-reactive antibody and CEA. " 07/01/1982 - "Lactosylsphingosine-reactive antibody and CEA in patients with colorectal cancer."
4.	Globoid Cell Leukodystrophy (Krabbe Disease) 08/15/1987 - "Lactosylsphingosine beta-galactosidase activities assayed in the absence and the presence of taurocholate (probably lactosylceramidase I) were deficient in fibroblasts from patients with globoid cell leukodystrophy, while the activity assayed with sodium cholate (probably lactosylceramidase II) was deficient in GM1 gangliosidosis fibroblasts. " 08/15/1987 - "In contrast, galactosylsphingosine beta-galactosidase was not activated by cholate and the enzyme activities assayed with the no-additive and taurocholate systems were deficient in brain and fibroblasts from patients with globoid cell leukodystrophy, thereby indicating that the hydrolysis of galactosylsphingosine is catalyzed by one enzyme, galactosylceramidase I. Exogenous lipids and an activator protein purified from normal spleen activated galactosylsphingosine beta-galactosidase but they were inhibitory to lactosylsphingosine beta-galactosidase. "

Related Drugs and Biologics

1.	Antibodies
2.	Sodium Cholate
3.	Cholates
4.	Taurocholic Acid (Sodium Taurocholate)
5.	Psychosine (Galactosylsphingosine)
6.	Proteins (Proteins, Gene)
7.	Lipids
8.	Galactosylceramidase
9.	Enzymes
10.	beta-Galactosidase (Lactaid)