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4-methylumbelliferyl oleate

Also Known As:

9-Octadecenoic acid (Z)-, 4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        Hymecromone: 123
        4-methylumbelliferyl oleate: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        Hymecromone: 123
        4-methylumbelliferyl oleate: 3

Experts

1.	Gu, Cong-min: 1 article (08/2012)
2.	He, Deng-min: 1 article (08/2012)
3.	Huang, Yong-lan: 1 article (08/2012)
4.	Li, Le: 1 article (08/2012)
5.	Liu, Hong-sheng: 1 article (08/2012)
6.	Liu, Li: 1 article (08/2012)
7.	Sheng, Hui-ying: 1 article (08/2012)
8.	Yu, Jia-kang: 1 article (08/2012)
9.	Zhao, Xiao-yuan: 1 article (08/2012)
10.	Kim, Ji Hyun: 1 article (07/2003)

Related Diseases

1.	Wolman Disease (Wolman's Disease) 08/01/2012 - "Lysosomal acid lipase activity was measured using 4-methylumbelliferyl oleate in the leukocytes of an infant suspected of Wolman disease and LIPA gene mutational analysis was performed by PCR and direct sequencing in the proband and his parents. "
2.	Obesity 07/01/2003 - "In the process of screening for pancreatic lipase inhibitors, which could be used as an anti-obesity measure, the methanol extract of Dioscorea nipponica Makino powder (DP) appeared to have potent inhibitory activity against porcine pancreatic lipase with an IC50 value of 5-10 microg/ml, where the enzyme activity was assayed by using 4-methylumbelliferyl oleate as a substrate. "
3.	Hypercholesterolemia 11/01/1986 - "Cholesterol esterification rates, measured by activity of acyl coenzyme A: cholesterol acyltransferase, increased moderately to markedly; hydrolase activity against 4-methylumbelliferyl oleate also increased at both acid and neutral pH, but hydrolase activity against cholesterol oleate increased only at acid pH. Thus, hypercholesterolemia caused striking increases in intracellular cholesterol esterification rates, increases in lipase activity at both neutral and acid pH, and increases in cholesteryl ester hydrolase activity at acid pH. Increases in cholesterol-esterifying activity uniformly exceeded increases in cholesteryl ester hydrolytic activity in congruence with net accumulation of cholesteryl ester. "

Related Drugs and Biologics

1.	Lipase (Acid Lipase)
2.	Powders
3.	Hydrolases
4.	Enzymes
5.	Cholesterol Esters (Cholesteryl Esters)
6.	Sterol Esterase (Hormone-Sensitive Lipase)
7.	Sterol O-Acyltransferase
8.	Cholesterol
9.	Methanol (Carbinol)
10.	Acyl Coenzyme A (Acyl CoA)