complestatin

compound extracted from Streptomyces lavendulae mycelia; on acid hydrolysis yields D-4-hydroxyphenylglycine & D-3,5-dichloro-4-hydroxyphenylglycine & acidic chromophore; inhibits gp120-CD4 binding

Also Known As:

chloropeptin II; isocomplestatin; Complestatin

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Chlorophenols: 95
        complestatin: 5
        Chlorobenzenes: 5
        Chlorophenols: 95
        complestatin: 5
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - complestatin: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - complestatin: 5

Experts

1.	Brun, Yves V: 1 article (01/2020)
2.	Coombes, Brian K: 1 article (01/2020)
3.	Culp, Elizabeth J: 1 article (01/2020)
4.	Fiebig-Comyn, Aline A: 1 article (01/2020)
5.	Hsu, Yen-Pang: 1 article (01/2020)
6.	Koteva, Kalinka: 1 article (01/2020)
7.	Sychantha, David: 1 article (01/2020)
8.	Van Nieuwenhze, Michael S: 1 article (01/2020)
9.	Waglechner, Nicholas: 1 article (01/2020)
10.	Wang, Wenliang: 1 article (01/2020)

Related Diseases

1.	Infections 08/30/1991 - "When MT-4 cells were pretreated with complestatin for 2 hrs prior to the exposure to HIV-1, the HIV-1-induced cytopathicity was markedly inhibited, while pretreatment of HIV-1 with the agent did not affect the infection. " 01/01/2020 - "Corbomycin and complestatin have low levels of resistance development and are effective in reducing bacterial burden in a mouse model of skin MRSA infection." 08/30/1991 - "Complestatin, an anti-complement agent, was shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) infection in vitro. "
2.	Ganglion Cysts (Ganglion) 10/01/2001 - "Finally, complestatin dose dependently prevented neuronal death evolving within the inner nuclear and ganglion cell layers, after transient retinal ischemia. "
3.	Neoplasms (Cancer) 12/01/2004 - "The nucleotide sequence of the 16S rRNA gene (1516 bp) of the TN58 strain showed high similarity (96-98%) to the Streptomyces 16S rRNA genes, especially with that of Streptomyces lavendulae which produces the anti-tumor compound mitomycin C, and the cyclic peptide antibiotic, complestatin. "
4.	Ischemia 10/01/2001 - "Finally, complestatin dose dependently prevented neuronal death evolving within the inner nuclear and ganglion cell layers, after transient retinal ischemia. "
5.	Hemolysis 02/01/1989 - "This compound inhibited the hemolysis of sensitized sheep erythrocytes (EA) mediated by guinea pig and human complement 50% at concentrations of 0.4 and 0.7 micrograms/ml, respectively, but did not trypsin and alpha-chymotrypsin activities at 200 micrograms/ml. When complestatin was administered intravenously to the sensitized guinea pigs, it strongly inhibited the systemic anaphylactic shock elicited by the antigen probably by blocking generation of anaphylatoxins (C3a and C5a)."

Related Drugs and Biologics

1.	corbomycin
2.	Complement System Proteins (Complement)
3.	Mitomycin (Mitomycin-C)
4.	Trypsin
5.	16S Ribosomal RNA
6.	Retinaldehyde (Retinal)
7.	Cyclic Peptides
8.	Antigens
9.	Anti-Bacterial Agents (Antibiotics)
10.	Anaphylatoxins