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guanosine 5'-O-(2-thiodiphosphate)
Also Known As:
GDP(beta-S); GDP-beta-S; guanyl-5'-yl thiophosphate; 5'-Guanylic acid, monoanhydride with phosphorothioic acid
Networked:
20
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleotides: 140
Guanine Nucleotides: 675
Guanosine Diphosphate: 1407
guanosine 5'-O-(2-thiodiphosphate): 20
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Ribonucleotides: 307
Guanine Nucleotides: 675
Guanosine Diphosphate: 1407
guanosine 5'-O-(2-thiodiphosphate): 20
Purine Nucleotides: 140
Guanine Nucleotides: 675
Guanosine Diphosphate: 1407
guanosine 5'-O-(2-thiodiphosphate): 20
Thionucleotides
guanosine 5'-O-(2-thiodiphosphate): 20
Organic Chemicals: 133
Sulfur Compounds: 278
Thionucleotides
guanosine 5'-O-(2-thiodiphosphate): 20
Experts
1.
Frye, Cheryl A
: 3 articles (09/2006 - 01/2004)
2.
Petralia, Sandra M
: 3 articles (09/2006 - 01/2004)
3.
Walf, Alicia A
: 1 article (09/2006)
Related Diseases
1.
Hyperalgesia
02/01/1995 - "
Hyperalgesia produced by all five analogs was significantly attenuated or completely blocked by inhibiting stimulatory guanine nucleotide-binding regulatory protein with guanosine 5'-O-(2-thiodiphosphate), adenylyl cyclase with 2'5'-dideoxyadenosine and protein kinase A with WIPTIDE.
"
09/01/1994 - "
Unlike prostaglandin E2, prostaglandin E1 hyperalgesia was not blocked by the inhibitor of the stimulatory guanine nucleotide-binding regulatory protein, guanosine 5'-O-(2-thiodiphosphate).
"
07/17/1989 - "
Although without effect alone, guanosine-5'-[gamma-thio]triphosphate (GTP gamma S) and cholera toxin--which activate Gs--both increased, while guanosine-5'-[beta-thio] diphosphate (GDP beta S)--which prevents the activation of Gs--decreased the hyperalgesia induced by PGE2.
"
01/01/1992 - "
In further support of the role of guanine nucleotide regulatory proteins, guanosine 5'-O-(2-thiodiphosphate), as well as activators of inhibitory guanine regulatory proteins (the mu-opioid agonist, [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin, and the adenosine A1 agonist, N6-cyclopentyladenosine, significantly attenuated 8-OH DPAT hyperalgesia.
"
06/01/1997 - "
Infusion of a G-protein inhibitor (GDP-beta-S), a general protein kinase inhibitor (H7), or selective inhibitors of protein kinase C (NPC15437), protein kinase A (H89), or protein kinase G (KT5823) into the spinal cord dorsal horn reversed the mechanical allodynia induced by intradermal injection of capsaicin in a dose-dependent manner by increasing the threshold to mechanical stimulation towards baseline.
"
2.
Lordosis
06/01/2006 - "
As well, D(1)-mediated increases in P-facilitated lordosis of rats and hamsters were inhibited by GDP-beta-S.
"
01/01/2004 - "
Both 3alpha,5alpha-THP- and 3alpha,5alpha-THP plus SKF38393-facilitated lordosis was reduced by VTA infusions of the G-protein inhibitor guanosine 5'-O-(2-thiodiphosphate) (GDP-beta-S; 50 microM), but not vehicle.
"
09/25/2006 - "
At hour 48, hamsters were pre-tested for lordosis and infused with the G-protein inhibitor, guanosine 5'-O-(2-thiodiphosphate) (GDP-beta-S, 50 microM/side), or 10% DMSO saline vehicle.
"
3.
Rupture
11/01/1993 - "
5. Internal perfusion of GTP gamma S or GDP beta S increased or did not affect the Ca2+ current and potentiation of Ca2+ current by Iso was unchanged and could be recorded repeatedly for about 20 min after rupture of the cell membrane.
"
05/01/1993 - "
On the other hand, 10 microM GTP gamma S directly activated the muscarinic K+ channel current within 60 sec after patch rupture in atrial myocytes; either GTP gamma S or GDP beta S (500 microM) occluded activation of this current by carbachol.
"
4.
Glioma (Gliomas)
04/15/1988 - "
Incubation of membranes of neuroblastoma x glioma hybrid, NG108-15 cells with GDP beta S followed by immunoblotting of resolved membrane and supernatant fractions with specific anti-peptide antisera showed essentially all of the alpha subunit of Go to be associated with the membrane.
"
05/29/1989 - "
In the presence of the beta-adrenergic agonist, isoproterenol, GDP beta S fails to support stimulation of C6 glioma membrane adenylate cyclase and inhibits GppNHp- or GTP gamma S-mediated stimulation of that enzyme.(ABSTRACT TRUNCATED AT 250 WORDS)
"
5.
Cholera
07/01/1994 - "
Pretreatment of pituitary cell cultures with cholera and pertussis toxin had no effect on the secretory response, whereas encapsulation of guanosine 5-[beta-thio]diphosphate (GDP-beta-S) by reversible electropermeabilization inhibited mastoparan-stimulated secretion.
"
03/01/1982 - "
However, in cholera toxic-treated membranes as well as in GDP-beta-S plus isoproterenol-treated membranes, fluoride-stimulated adenylate cyclase activity is significantly reduced, but vanadate stimulation is not.
"
Related Drugs and Biologics
1.
GTP-Binding Proteins (G-Protein)
2.
Guanosine 5'-O-(3-Thiotriphosphate)
3.
guanosine 5'-O-(2-thiodiphosphate)
4.
Proteins (Proteins, Gene)
5.
Adenylyl Cyclases (Adenylyl Cyclase)
6.
Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
7.
Dinoprostone (PGE2)
8.
Diphosphates (Pyrophosphates)
9.
Isoproterenol (Isoprenaline)
10.
Guanosine Diphosphate (GDP)
Related Therapies and Procedures
1.
Intradermal Injections