UDPacetylglucosamine pyrophosphorylase

forms UDP-N-acetylglucosamine from N-acetylglucosamine- 1-phosphate and UTP; also catalyzes acetylation of glucosamine-1-phosphate

Also Known As:

GlcNAc 1-P uridyltransferase; N-acetylglucosamine 1-phosphate uridyltransferase; N-acetylglucosamine-1-phosphate uridyltransferase; UAP1L1 protein, human; UDP-GlcNAcpyrophosphorylase; UDP-N-acetylglucosamine pyrophosphorylase; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 protein, human; glucoseamine-1-phosphate acetyltransferase; uridine diphosphoglucosamine pyrophosphorylase

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Nucleotidyltransferases: 29
        UDPacetylglucosamine pyrophosphorylase: 8

Experts

1.	Karpoormath, Rajshekhar: 1 article (08/2020)
2.	Palkar, Mahesh: 1 article (08/2020)
3.	Patel, Harun M: 1 article (08/2020)
4.	Chen, Mingzhou: 1 article (01/2020)
5.	Chen, Xingwu: 1 article (01/2020)
6.	Chen, Xinwen: 1 article (01/2020)
7.	Kemper, Thekla: 1 article (01/2020)
8.	Li, Mengqi: 1 article (01/2020)
9.	Lin, Yong: 1 article (01/2020)
10.	Liu, Hongbing: 1 article (01/2020)

Related Diseases

1.	Tuberculosis (Tuberculoses) 08/01/2020 - "tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmUMTB ) inhibitors to overcome the problem of the MDR-TB. " 02/15/2016 - "tuberculosis, with special emphasis put on N-acetylglucosamine-1-phosphate uridyltransferase (GlmU), a bifunctional enzyme, which catalyzes the last two steps of this pathway. "
2.	Cysts 11/25/2005 - "The UDP-N-acetylglucosamine pyrophosphorylase in Giardia intestinalis (GiUAP) is one of the five inducible enzymes to synthesize UDP-GalNAc, which is an important precursor for cyst wall synthesis. " 05/12/2000 - "Giardia synthesizes UDP-GalNAc during cyst wall formation (encystment) via a pathway of inducible enzymes similar to that used to synthesize chitin or peptidoglycan and that includes the UTP-requiring UDP-N-acetylglucosamine pyrophosphorylase. "
3.	Vesicular Stomatitis 01/01/2020 - ": ACTB: actin beta; ATG: autophagy-related; CMIA: chemiluminescence immunoassay; ConA: concanavalin A; CQ: chloroquine; CTSD: cathepsin D; DAPI: 4',6-diamidino-2-phenylindole; EV71: enterovirus 71; GalN: galactosamine; GFP: green fluorescence protein; GlcN: glucosamine; GNPNAT1: glucosamine-phosphate N-acetyltransferase 1; HBP: hexosamine biosynthesis pathway; HBV: hepatitis B virus; HBcAg: hepatitis B core antigen; HBsAg: hepatitis B surface antigen; HBeAg: hepatitis B e antigen; HBV RI: hepatitis B replicative intermediate; IAV: influenza A virus; LAMP1: lysosomal associated membrane protein 1; LAMTOR: late endosomal/lysosomal adaptor, MAPK and MTOR activator; ManN: mannosamine; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; PHH: primary human hepatocyte; RAB7: RAB7A, member RAS oncogene family; RPS6KB1: ribosomal protein S6 kinase B1; RRAGA: Ras related GTP binding A; RT-PCR: reverse transcriptase polymerase chain reaction; SEM: standard error of the mean; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; UAP1: UDP-N-acetylglucosamine pyrophosphorylase 1; VSV: vesicular stomatitis virus."
4.	Respiratory Syncytial Virus Infections 01/01/2022 - "To elaborate this mechanism of HBP expression, we demonstrate that RSV infection coordinately induces the HBP pathway enzymes in a manner requiring RELA; these genes include Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT)-1/2, Glucosamine-Phosphate N-Acetyltransferase (GNPNAT)-1, phosphoglucomutase (PGM)-3 and UDP-N-Acetylglucosamine Pyrophosphorylase (UAP)-1. "
5.	Prostatic Neoplasms (Prostate Cancer) 07/01/2015 - "Here we assess the levels of all hexosamine biosynthetic pathway (HBP) enzymes in 15 separate clinical gene expression data sets and identify the last enzyme in the pathway, UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1), to be highly overexpressed in prostate cancer. "

Related Drugs and Biologics

1.	Enzymes
2.	Glucosamine 6-Phosphate N-Acetyltransferase (Glucosamine-Phosphate N-Acetyltransferase)
3.	Uridine Diphosphate (UDP)
4.	Hexosamines
5.	Lysosomal-Associated Membrane Protein 1
6.	Small Interfering RNA (siRNA)
7.	Sirolimus (Rapamycin)
8.	Ribosomal Protein S6 Kinases (S6 Kinase)
9.	Uridine Triphosphate (UTP)
10.	RNA-Directed DNA Polymerase (Reverse Transcriptase)