phosphoinositide 5-phosphatase

Also Known As:

INPP5B protein, human; INPP5E protein, human; INPP5G protein, human; INPP5H protein, human; Inpp5e protein, mouse; SYNJ1 protein, human; SYNJ2 protein, human; inositol polyphosphate 5-phosphatase type IV; inositol polyphosphate-5-phosphatase E, human; inositol polyphosphate-5-phosphatase, 72 kDa protein, human; inositol polyphosphate-5-phosphatase, 75kDa, human; pharbin protein, rat; phosphatidyl-inositol-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphomonoesterase; phosphatidylinositol-4,5-bisphosphate-5-phosphatase; phosphatidylinositol-bisphosphatase; phospholipid-specific inositol polyphosphate 5-phosphatase; ptdIns(4,5)P2 5-phosphatase; synaptojanin 1 protein, human; synaptojanin 2 protein, human; triphosphoinositide phosphatase; type IV 5-phosphatase

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        phosphoinositide 5-phosphatase: 10

Experts

1.	Erneux, Christophe: 2 articles (01/2019 - 01/2018)
2.	Ramos, Ana Raquel: 2 articles (01/2019 - 01/2018)
3.	Lowe, Martin: 2 articles (01/2016 - 04/2012)
4.	Fratini, Marta: 1 article (01/2021)
5.	Heilmann, Ingo: 1 article (01/2021)
6.	Rausche, Juliane: 1 article (01/2021)
7.	Rosahl, Sabine: 1 article (01/2021)
8.	Stauder, Ron: 1 article (01/2021)
9.	Stenzel, Irene: 1 article (01/2021)
10.	Trujillo, Marco: 1 article (01/2021)

Related Diseases

1.	Oculocerebrorenal Syndrome (Lowe Syndrome) 04/15/2012 - "Lowe syndrome, which is characterized by defects in the central nervous system, eyes and kidneys, is caused by mutation of the phosphoinositide 5-phosphatase OCRL1. " 07/01/2019 - "Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P2 on membranes and, ultimately, Lowe syndrome. " 06/26/2011 - "Here, we report that the phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) 5-phosphatase OCRL, which is mutated in Lowe syndrome patients, is an effector of the Rab35 GTPase in cytokinesis abscission. " 01/01/2016 - "Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. "
2.	Glioblastoma (Glioblastoma Multiforme) 01/01/2019 - "Here, we compared phosphoinositide 5-phosphatases expression in glioblastoma primary cells and cell lines and showed that SHIP2 and SKIP expression greatly varies between different cell types, while OCRL, another phosphoinositide 5-phosphatase, is constitutively expressed. " 01/01/2019 - "Two members of the phosphoinositide 5-phosphatase family, SKIP and SHIP2, have been associated with cell migration in glioblastoma; however, the precise role these enzymes play in the process-and whether they work in concert-remains unclear. " 01/01/2018 - "Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved."
3.	Cognitive Dysfunction 03/02/2017 - "Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment."
4.	Muscular Dystrophies (Muscular Dystrophy) 03/02/2017 - "These data link congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity that is becoming increasingly recognized for its role in mediating pivotal cellular mechanisms contributing to disease." 03/02/2017 - "Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment."
5.	Infections 01/01/2021 - "A phosphoinositide 5-phosphatase from Solanum tuberosum is activated by PAMP-treatment and may antagonize phosphatidylinositol 4,5-bisphosphate at Phytophthora infestans infection sites."

Related Drugs and Biologics

1.	Phosphatidylinositols (Phosphatidylinositol)
2.	GTP Phosphohydrolases (GTPases)
3.	Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Diphosphate)
4.	Phosphotransferases (Kinase)
5.	Phosphoric Monoester Hydrolases (Phosphatases)
6.	Enzymes
7.	Antibodies
8.	Pathogen-Associated Molecular Pattern Molecules
9.	phosphoinositide-3,4-bisphosphate