choloylglycine hydrolase

also acts on choloyltaurine (taurocholic acid)

Also Known As:

3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylcglycine amidohydrolase; BSHalpha; BSHbeta; bile salt hydrolase; cbsHalpha; cbsHbeta; cholanoyl amino acid hydrolase; cholylglycine hydrolase; cholyltaurine hydrolase; glycocholase; glycocholic acid hydrolase

Networked: 50 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - choloylglycine hydrolase: 50

Experts

1.	Cho, Jennifer Y: 2 articles (01/2022 - 01/2020)
2.	Hsiao, Ansel: 2 articles (01/2022 - 01/2020)
3.	Liu, Rui: 2 articles (01/2022 - 01/2020)
4.	Ai, Lianzhong: 2 articles (01/2020 - 03/2019)
5.	Cabanes, Didier: 2 articles (01/2020 - 08/2002)
6.	Cossart, Pascale: 2 articles (01/2020 - 08/2002)
7.	Huang, Wenli: 2 articles (01/2020 - 03/2019)
8.	Wang, Guangqiang: 2 articles (01/2020 - 03/2019)
9.	Xia, Yongjun: 2 articles (01/2020 - 03/2019)
10.	Xiong, Zhiqiang: 2 articles (01/2020 - 03/2019)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 01/01/2023 - "Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity." 01/01/2020 - "Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model." 08/11/2023 - "The intestinal bacteria regulate the metabolism of bile acids depending on bile salt hydrolase (BSH), 7-dehydroxylation, hydroxysteroid dehydrogenase (HSDH), or amide conjugation reaction, thus exerting effects on NAFLD development through bile acid receptors such as farnesoid X receptor (FXR), Takeda G-protein-coupled bile acid protein 5 (TGR5), and vitamin D receptor (VDR), which modulate nutrient metabolism and insulin sensitivity via interacting with downstream molecules. "
2.	Weight Gain 05/20/2014 - "Using this approach we show that bacterial bile salt hydrolase (BSH) mediates a microbe-host dialogue that functionally regulates host lipid metabolism and plays a profound role in cholesterol metabolism and weight gain in the host. " 02/01/1987 - "Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity." 02/01/1987 - "The inverse relationship between growth performance and cholyltaurine hydrolase activity raises the possibility that specific inhibitors of this enzyme may promote weight gain and feed conversion in livestock and thereby reduce or eliminate the need for antibiotic feed additives." 01/01/2021 - "GQD can improve the general state of T2DM rats, slow down their weight gain, reduce the levels of fasting blood glucose, fasting insulin, glycosylated hemoglobin, blood ceramide, bile salt hydrolase in intestinal tissue, and acetyl CoA in liver mitochondria of T2DM rats, and increase the contents of liver glycogen and T-β-MCA in blood of T2DM rats. " 02/01/1987 - "Avoparcin, bacitracin methylenedisalisylic acid, efrotomycin, lincomycin, penicillin G procaine, and virginiamycin improved rate of weight gain and feed conversion of chicks and decreased cholyltaurine hydrolase activity in ileal homogenates relative to those of nonmedicated control birds. "
3.	Weight Loss (Weight Reduction) 01/01/2022 - "Bile salt hydrolase (BSH) enzymes produced by intestinal Lactobacillus species have been recognized as major targets for probiotic studies owing to their weight-loss and cholesterol-lowering effects. "
4.	Dysbiosis 08/18/2023 - "Meanwhile, SPN alleviated D-gal-induced gut dysbiosis and reversed the proportions of microbes associated with bile salt hydrolase activity, including Lactobacillus, Ruminiclostridium, and Butyrivibrio. " 06/01/2023 - "AFB1 exposure induced gut microbiota dysbiosis and reduced fecal bile salt hydrolase (BSH) activity. " 08/10/2022 - "Moreover, PCPE treatment alleviated gut dysbiosis, especially reducing the relative abundance of bile salt hydrolase (BSH)-producing bacteria. " 01/01/2021 - "Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. " 11/25/2022 - "Cd exposure induced gut microbiota dysbiosis and reduced the fecal bile salt hydrolase activity leading to an increase of tauro-β-muricholic acid levels in the intestine. "
5.	Infections 01/01/2007 - "A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in mice." 01/01/2020 - "During late infection, in absence of CadC-dependent repression, the constitutive bile salt hydrolase expression induces the overexpression of the cholic acid efflux pump MdrT that is unfavorable to Lm virulence. " 01/01/2020 - "Using transplantation of human microbiomes into several animal models of infection, we show that key microbiome species shape the chemical environment of the gut through the activity of the enzyme bile salt hydrolase. " 01/01/2022 - "We also show that susceptible and infection-resistant microbes drive different bile acid compositions in vivo by the action of bile salt hydrolase enzymes. "

Related Drugs and Biologics

1.	Acids
2.	Virginiamycin
3.	Penicillin G Procaine (Procaine, Benzylpenicillin)
4.	Lincomycin (Lincocin)
5.	Bacitracin (Baci-Rx)
6.	caffeic acid phenethyl ester
7.	avoparcin
8.	efrotomycin
9.	Cholesterol
10.	Enzymes

Related Therapies and Procedures

1.	Transplantation