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thymidine-triphosphatase
Also Known As:
dTTPase; deoxythymidinetriphosphatase; thymidine-5'-triphosphatase; thyminedeoxyribonucleasetriphosphatase
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Acid Anhydride Hydrolases
Pyrophosphatases: 171
thymidine-triphosphatase: 6
Related Diseases
1.
Neoplasms (Cancer)
01/01/1991 - "
The more advanced the disease or the less aggressive the tumor, the higher the dTTPase activity.
"
01/01/1991 - "
The results showed a significant correlation between dTTPase activity and the onset of proliferation (studied in mice), as well as the grade of malignancy (studied in men).
"
02/01/1984 - "
While dTTPase levels rise in patients with increasing tumor burdens, they decline in patients with undetectable tumor tissue after radical surgery.
"
02/01/1984 - "
The dTTPase values of patients in Duke's Stage B and C are significantly elevated over normal healthy controls, and a correlation was observed between tumor stage and dTTPase activity.
"
02/01/1984 - "
Serum deoxythymidine-5'-triphosphatase (dTTPase) levels were determined in 71 patients with large bowel cancers at different clinical stages: 10 patients in Duke's Stage A; 37, in Duke's Stage B; and 24, in Duke's Stage C.
"
2.
Infections
05/01/1980 - "
The nucleotide pools of infected cells did not contain dTTP, and infection resulted in the appearance of dTTPase activity.
"
04/01/1974 - "
After infection of Bacillus cereus 569-SP1 with the 5-hydroxymethyluracil-containing phage GSW, new dTTPase, dUTPase, and dUMP-hydroxymethylase activities appear.
"
3.
Colorectal Neoplasms (Colorectal Cancer)
02/01/1984 - "
So, if both dTTPase and carcinoembryonic antigen are taken into account, the sensitivity of detection of colorectal carcinomas rises to 66% for all patients and to 92% for patients with a colorectal carcinoma of Duke's Stage C.
"
4.
Plasmacytoma
01/01/1991 - "
A recently discovered enzyme of the pyrimidine pathway, deoxythymidine-5'-triphosphatase (dTTPase), was estimated in sera from leukemic mice and 64 untreated patients with non-Hodgkin's lymphoma (NHL) as well as 30 patients with plasmocytoma.
"
5.
Non-Hodgkin Lymphoma (Lymphosarcoma)
01/01/1991 - "
A recently discovered enzyme of the pyrimidine pathway, deoxythymidine-5'-triphosphatase (dTTPase), was estimated in sera from leukemic mice and 64 untreated patients with non-Hodgkin's lymphoma (NHL) as well as 30 patients with plasmocytoma.
"
Related Drugs and Biologics
1.
Carcinoembryonic Antigen
2.
CA-19-9 Antigen (CA 19-9 Antigen)
3.
Tumor Biomarkers (Tumor Markers)
4.
Thymidine Kinase
5.
Nucleotides
6.
Enzymes
7.
Carbohydrates
8.
squamous cell carcinoma-related antigen
9.
pyrimidine
10.
thymidine 5'-triphosphate (thymidine triphosphate)