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folylpolyglutamate synthetase

catalyze the formation of amide bond between gamma-carboxyl of a folate and amino group of glutamic acid folate; any folic acid including polyglutamates; RefSeq NM_120680 (FPGS1, Arabidopsis)
Also Known As:
FPGS1 protein, Arabidopsis; MET23 protein; MET7 protein; MET7 protein, S cerevisiae; folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase; tetrahydrofolylpolyglutamate synthase
Networked: 94 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Assaraf, Yehuda G: 7 articles (01/2021 - 02/2003)
2. Jansen, Gerrit: 6 articles (01/2021 - 02/2003)
3. Cloos, Jacqueline: 4 articles (01/2021 - 01/2016)
4. Gustavsson, Bengt: 4 articles (07/2008 - 12/2003)
5. Nilsson, Staffan: 4 articles (07/2008 - 12/2003)
6. Odin, Elisabeth: 4 articles (07/2008 - 12/2003)
7. Wettergren, Yvonne: 4 articles (07/2008 - 12/2003)
8. Wojtuszkiewicz, Anna: 3 articles (01/2021 - 01/2016)
9. Carlsson, Göran: 3 articles (07/2008 - 12/2003)
10. Gangjee, Aleem: 3 articles (02/2008 - 05/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
3. Leukemia
4. Colorectal Neoplasms (Colorectal Cancer)
07/01/2008 - "Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients. "
01/01/1999 - "Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors."
01/01/2005 - "Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients."
12/01/2003 - "Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102). "
02/01/2016 - "In this study, primary tumors obtained from 1,129 patients with colorectal cancer were used to measure the mRNA expression levels of the following genes associated with the effects of standard chemotherapy for colorectal cancer: 5-fluorouracil (5-FU)-related thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP); folate-related dihydrofolate reductase (DHFR), folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross-complementing 1 (ERCC1); biologic agent-related vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR). "
5. Head and Neck Neoplasms (Head and Neck Cancer)

Related Drugs and Biologics

1. Methotrexate (Mexate)
2. Folic Acid (Vitamin M)
3. Folic Acid Antagonists
4. Thymidylate Synthase
5. gamma-Glutamyl Hydrolase (Carboxypeptidase G2)
6. Messenger RNA (mRNA)
7. Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
8. Fluorouracil (Carac)
9. Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
10. Thymidine Phosphorylase

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Adjuvant Chemotherapy
3. Therapeutics