tosylarginine methyl ester hydrolase (tamase)

protease from sea urchin (Arbacia punctulata) eggs; fertilization in the sea urchin is accompanied by the release of this protease from eggs into the surrounding seawater; enzyme uses TAME as substrate; used as a measure of trypsin-like activity; tryptase (formerly here) is mast cell tryptase (EC 3.4.21.59)

Also Known As:

Networked: 39 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gunny, Fatmah Bibi Housnah: 1 article (01/2004)
2.	Subratty, Anwar Hussein: 1 article (01/2004)
3.	Gurib, F B H: 1 article (05/2002)
4.	Subratty, A H: 1 article (05/2002)

Related Diseases

1.	Sneezing 02/01/1992 - "After a single dose of azelastine, there was a significant reduction in sneezing (10 vs 2, P = 0.01) and in the median levels of recovered TAME-esterase activity (63.1 vs 17.5 c.p.m. " 01/01/1990 - "Captopril had no significant effects on histamine, TAME-esterase, sneezing or symptom scores. " 12/01/1989 - "Compared with placebo, both antihistamines significantly reduced sneezing and the levels of recovered albumin and TAME esterase activity, suggesting that both reduced the expected increase in vascular permeability. " 01/01/1989 - "Sneezing, blockage, and secretions were associated with increased concentrations of TAME esterase (maximum 9000 cpm/ml), kinins (1.4 ng/ml), and albumin (0.3 g/l) in lavage fluid. " 12/01/1985 - "The immunized group had a diminished response as demonstrated by (a) the treated group required higher pollen doses to excite sneezing or mediator release; (b) significantly fewer subjects in the treated group released mediators at any dose (TAME-esterase [P = 0.005], PGD2 [P = 0.04]), and (c) the treated group released 3-5-fold less mediator (TAME-esterase [P = 0.01], and histamine [P = 0.02])."
2.	Inflammation (Inflammations) 03/01/1996 - "The purpose of our study was to evaluate the effects of laser turbinectomy on local allergic inflammation by measuring the secretion of mediators (histamine, bradykinin, and TAME-esterase activity) in nasal lavage fluid after nasal provocation with different allergen concentrations. " 07/01/1995 - "The purpose of our study was to evaluate the effects of laser turbinectomy on local allergic inflammation by measuring the secretion of mediators (histamine, bradykinin, and TAME-esterase activity) in nasal lavage fluid after nasal provocation with different allergen concentrations. "
3.	Anaphylaxis (Anaphylactic Shock) 04/01/1980 - "A study of the effect of acute systemic anaphylaxis on blood coagulation and TAME esterase activity in calves."
4.	Rhinorrhea 08/01/1995 - "Compared with baseline, cold dry air induced significant rhinorrhea and increased both secretion weights (9.6 +/- 1.3 vs. 28.1 +/- 6.5 mg; P = 0.01) and the levels of histamine (3.9 +/- 1.2 vs. 10.6 +/- 2.7 ng/ml; P = 0.02) and TAME esterase activity (3.1 +/- 0.8 vs. 7.0 +/- 2.0 counts.min-1.10(-3); P = 0.01). " 08/01/1992 - "Even with atropine, however, rhinorrhea and TAME-esterase activity were still significantly increased over the prechallenge baseline. " 08/01/1988 - "All 12 subjects showed an immediate response, whereas 8 had a LPR, as indicated by a recurrence of symptoms (rhinorrhea and congestion) hours later, accompanied by an increase in the levels of histamine and TAME-esterase activity. " 04/01/1991 - "Between-group analysis revealed that IT significantly reduced the levels of histamine, TAME-esterase activity, and kinins, as well as symptoms of rhinorrhea and congestion generated during the ER to nasal challenge. " 08/01/1992 - "Atropine significantly reduced rhinorrhea, the levels of histamine, and TAME-esterase activity as well as the osmolality of recovered lavage fluids, but had no effect on nasal congestion or albumin. "
5.	Hypertension (High Blood Pressure) 05/01/2002 - "It is suggested that conclusions TAME-esterase could be an important biological marker associated with onset of vascular discases such as hypertension." 10/01/1981 - "Kallikrein TAME esterase activity was the same in 1 1/2-month-old S and R rats but became reduced in S relative to R rats at 3 and 6 months of age, concomitant with the development of hypertension and marked proteinuria. " 10/01/1981 - "We conclude that (1) reduced excretion of urinary kallikrein TAME esterase activity in S rats is probably secondary to hypertension and severe proteinuria and (2) decreased urinary PGE2 excretion in prehypertensive S rats is compatible with, but does not prove, the presence of a primary defect in intrarenal PGE2 production that could be involved in initiating hypertension." 09/01/1984 - "Estimations of prekallikrein and kallikrein inhibitor by means of TAME-esterase method and of the content of kininogen by biological procedure were carried out in blood plasma, isolated from right and left ventricles of heart, of rats with spontaneous hypertension, Okamoto-Aoki strain, and of the normotensive animals Wistar-Kyoto strain. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Albumins
3.	Prostaglandin D2
4.	Leukotriene C4
5.	azelastine (Optivar)
6.	Bradykinin
7.	Allergens
8.	Kinins
9.	arginine methyl ester
10.	Kallikreins (Kallikrein)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Premedication
3.	Immunotherapy