7-ketolithocholic acid

RN given refers to (3alpha,5beta)-isomer

Also Known As:

3 alpha-hydroxy-7-keto-5 beta-cholanoate; 3 alpha-ol-7-one-5 beta-cholanoic acid; 7-ketolithocholic acid, (3beta,5alpha)-isomer; 7-oxolithocholic acid; (3 alpha,5 beta)-3-hydroxy-7-oxocholan-24-oic acid

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Bile Acids and Salts: 11432
      - Cholic Acids: 14
        Lithocholic Acid: 316
        7-ketolithocholic acid: 6
    - Cholanes
      - Cholic Acids: 14
        Lithocholic Acid: 316
        7-ketolithocholic acid: 6

Related Diseases

1.	Gallstones (Gallstone) 09/01/1980 - "To define the metabolism of 7-ketolithocholic acid in man, studies were carried out in gallstone patients with normal liver function. " 08/01/1982 - "The reduction in biliary lithogenic index and in cholesterol concentration suggest that low doses of 7-ketolithocholic acid may be effective in dissolving gallstones." 08/01/1982 - "The effect of 7-ketolithocholic acid on biliary bile acid composition, cholesterol saturation, and as an intermediate in the conversion of chenodeoxycholic acid to ursodeoxycholic acid was investigated in 5 subjects with gallstones. "
2.	Fistula 07/01/1990 - "When a mixture of [3H]ursodeoxycholic acid and [14C]chenodeoxycholic acid was infused into another bile fistula guinea pig, little 3H could be detected in either chenodeoxycholic acid or 7-ketolithocholic acid. " 03/01/1986 - "Injection of either [14C]cholesterol, [14C]ursodeoxycholic, [14C]7-ketolithocholic acid, or a mixture of [7 beta-3H]chenodeoxycholic acid and [14C]chenodeoxycholic acid into bile fistula nutria demonstrated that all three bile acids can be synthesized hepatically from cholesterol, that they are interconverted sparingly (2%-5%) by the liver, but that 7-ketolithocholic acid is an intermediate in the hepatic transformation of chenodeoxycholic acid to ursodeoxycholic acid. "
3.	Gallbladder Diseases (Gall Bladder Disease) 09/01/2023 - "Chenodeoxycholic acid, glycochenodeoxycholic acid, λ-muricholic acid, deoxycholic acid, and 7-ketolithocholic acid were shared potential markers of these two cholesterol gallbladder diseases. "
4.	Crohn Disease (Crohn's Disease) 03/01/1986 - "These observations suggest that 7-ketolithocholic acid is an intermediate of this biotransformation in patients with Crohn's disease." 03/01/1986 - "In vivo 7 beta-epimerization of chenodeoxycholic acid to ursodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in 11 patients with Crohn's disease and in 5 healthy volunteers. "

Related Drugs and Biologics

1.	Cholesterol
2.	Chenodeoxycholic Acid (Chenix)
3.	Ursodeoxycholic Acid (Urso)
4.	Bile Acids and Salts (Bile Acids)
5.	Glycochenodeoxycholic Acid (Glycochenodeoxycholate)
6.	Deoxycholic Acid (Sodium Deoxycholate)
7.	Acids
8.	muricholic acid