colonization factor antigens

protein found on plasmid-mediated fimbriae from enteropathogenic strains of E coli; known to confer adhesive & colonizing properties for intestinal epithelium of several domestic animals & man to host strain; has been sequenced; GenBank X97494

Also Known As:

CFA-1 (fimbrial); KS 71A fimbrial antigen; colonization factor CS19; colonization factor CSS; colonization factor antigen III; colonization factor antigen-1; colonization factor antigen-2; colonization factor antigen-3; fimbrial antigen F7(1); fimbrial colonization factor antigen-1

Networked: 29 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Bacterial Outer Membrane Proteins: 9
      - Fimbriae Proteins: 109
        colonization factor antigens: 29
  - Bacterial Proteins: 394
    - Bacterial Outer Membrane Proteins: 9
      - Fimbriae Proteins: 109
        colonization factor antigens: 29

Experts

1.	Sack, David A: 4 articles (09/2015 - 05/2007)
2.	Zhang, Weiping: 4 articles (09/2015 - 01/2010)
3.	Arimizu, Yoko: 1 article (01/2020)
4.	Gotoh, Yasuhiro: 1 article (01/2020)
5.	Hayashi, Tetsuya: 1 article (01/2020)
6.	Ishimaru, Kai: 1 article (01/2020)
7.	Nakamura, Keiji: 1 article (01/2020)
8.	Narimatsu, Hiroshi: 1 article (01/2020)
9.	Ogura, Yoshitoshi: 1 article (01/2020)
10.	Sasaki, Mari: 1 article (01/2020)

Related Diseases

1.	Infections 07/01/2012 - "Adhesion is the first step in pathogenesis of ETEC infections and ETEC pili designated colonization factor antigens (CFAs) are believed to be important in the biofim formation, colonization and host cell adhesions. " 07/01/1979 - "Response to the colonization-factor antigens correlated significantly with response to the heat-labile toxin and with culture evidence of ETEC infection. " 10/01/2004 - "On infection, ETEC first establishes itself by adhering to the epithelium of the small intestine via one or more colonization factor antigens or coli surface proteins. " 07/01/1979 - "To improve the retrospective diagnoses of enterotoxigenic Escherichia coli (ETEC) as a cause of travelers' diarrhea, as well as to determine the presence of colonization-factor antigens in these infections, a study of serologic responses to antigens of ETEC was done. " 10/01/1985 - "The diarrheal response to an initial and a second infection with Escherichia coli expressing various enterotoxins (the heat-stable toxin [ST] alone or in combination with the heat-labile toxin [LT]) and colonization factor antigens (CFA/I, CFA/II, or E8775-type) was studied in the reversible tie adult rabbit diarrhea model. "
2.	Diarrhea 01/01/2020 - "coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. " 02/01/2006 - "Oral delivery of toxin-negative derivatives of enterotoxigenic Escherichia coli (ETEC) that express colonization factor antigens (CFA) with deletions of the aroC, ompC, ompF, and toxin genes may be an effective approach to vaccination against ETEC-associated diarrhea. " 10/01/2002 - "Colonization factor antigens (CFA)/I- and CFA/II-expressing enterotoxigenic Escherichia coli (ETEC) strains constitute one of the main causes of diarrhea in infants. " 02/01/1997 - "Distribution of colonization factor antigens among enterotoxigenic Escherichia coli strains isolated from patients with diarrhea in Nepal, Indonesia, Peru, and Thailand." 10/01/1996 - "Colonization factor antigens (CFAs) mediate attachment of enterotoxigenic Escherichia coli (ETEC) to the intestinal mucosa and induce protective immunity against ETEC diarrhea. "
3.	Cholera 07/01/1998 - "coli bacteria expressing the most common colonization factor antigens (CFAs), i.e., CFA/I, -II, and -IV, and recombinantly produced cholera B subunit (CTB). " 05/30/2007 - "We tested the efficacy of a killed oral vaccine for enterotoxigenic Escherichia coli (ETEC) diarrhoea to determine if two doses of vaccine with colonization factor antigens (CF) and cholera B subunit would protect against ETEC diarrhoea of travellers. " 01/01/1993 - "A prototype oral enterotoxigenic Escherichia coli (ETEC) vaccine containing formalin-inactivated whole bacteria expressing colonization factor antigens CFA/I and CFA/II and cholera B subunit (CTB) has been tested for safety and immunogenicity in 20 adult Swedish volunteers. "
4.	Reinfection 01/01/2005 - "Recent experiences have questioned the validity of the current vaccine strategy since new reports indicate that (1) the number of recognized colonization factor antigens of ETEC has increased to more than 21, (2) epidemiologic field studies of children in endemic areas suggest that infection with ETEC of a given colonization factor antigen/toxin phenotype may not confer protection on reinfection with other strains of the same colonization factor antigen/toxin phenotype, and (3) a major field trial of a heat-killed ETEC vaccine expressing colonization factor antigens and containing the B subunit of cholera toxin as a surrogate for E. "
5.	Urinary Tract Infections (Urinary Tract Infection) 07/01/1982 - "We and other investigators have found that HA type VI fimbriae may function as colonization factor antigens, especially in urinary tract infections. "

Related Drugs and Biologics

1.	Vaccines
2.	Enterotoxins (Enterotoxin)
3.	Shiga Toxins (Vero Toxin)
4.	Antigens
5.	Cholera Toxin
6.	Virulence Factors (Pathogenicity Factors)
7.	Subunit Vaccines
8.	Peptides (Polypeptides)
9.	Membrane Proteins (Integral Membrane Proteins)
10.	Formaldehyde (Formol)