isoborneol (borneol)

RN given refers to cpd without isomeric designation; structure

Also Known As:

borneol; isoborneol, (1R-endo)-isomer; isoborneol, (1R-exo)-isomer; isoborneol, (1S-endo)-isomer; isoborneol, (1S-exo)-isomer; isoborneol, (endo)-isomer; isoborneol, (endo-(+-))-isomer; isoborneol, (exo)-isomer

Networked: 169 relevant articles (24 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Jian: 8 articles (02/2022 - 09/2011)
2.	Bai, Jie: 6 articles (04/2018 - 11/2012)
3.	Lu, Yang: 6 articles (04/2018 - 11/2012)
4.	Ma, Rong: 5 articles (02/2022 - 06/2018)
5.	Xie, Qian: 5 articles (02/2022 - 06/2018)
6.	Ruan, Ming: 5 articles (01/2021 - 01/2016)
7.	Yu, Bin: 5 articles (01/2021 - 01/2016)
8.	Chen, Tianfeng: 5 articles (10/2020 - 01/2013)
9.	Li, Hongyan: 4 articles (02/2022 - 01/2021)
10.	Li, Yong: 4 articles (02/2022 - 01/2021)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 03/01/2023 - "[Protective effects of three kinds of borneol on different brain regions in acute cerebral ischemia/reperfusion model rats]." 01/01/2014 - "The objective of this paper was to study the anti-cerebral ischemia effect of borneol and its mechanism. " 01/01/2014 - "Study on the anti-cerebral ischemia effect of borneol and its mechanism." 01/01/2022 - "However, it remains unclear whether borneol can promote entry of the active components of AST IV and PNS into the brain tissues and enhance their effect against cerebral ischemia. " 01/01/2021 - "Conclusions: The results indicated that LCH and borneol were complementary to each other in attenuating brain ischemia by and large. "
2.	Ischemic Stroke 01/01/2021 - "Results: Borneol is effective in the prevention and treatment of nerve injury in ischemic stroke. " 09/01/2023 - "The study will provide a reference for the use of l-borneol in the treatment of ischemic stroke in the subacute phase." 01/01/2019 - "Fifteen studies investigated the effects of borneol in experimental ischemic stroke involving 308 animals were ultimately identified. " 01/01/2019 - "The studies of borneol for ischemic stroke in animal models were included. " 07/13/2017 - "However, no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown. "
3.	Neoplasms (Cancer) 01/01/2021 - "Thus, based on the penetration ability and the inhibition drug efflux of borneol, it was expected to increase the targeting and detention efficacy of drugs into tumor sites in nanocarriers with borneol modification. " 06/01/2016 - "[Effect of Borneol on the Permeability of Blood Tumor Barrier Model and its Mechanism Study]." 07/26/2022 - "Cotreatment with d-borneol and CDDP inhibited tumor growth in vivo and reduced CDDP-caused liver and kidney toxicity. " 01/01/2018 - "Natural borneol (NB) has been identified as a potential chemosensitizer in treating human cancers. " 04/01/2016 - "Its encapsulation efficiency, drug loading ratio, particle size distribution, Zeta potential, morphology and in vitro drug release behavior were characterized, and synergistic effect with borneol in resisting tumor activity were preliminarily studied by MTT. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 09/01/2023 - "We herein investigated the cerebral protective effects of l-borneol on neurovascular units (NVU) in the subacute phase after transient middle cerebral artery occlusion (t-MCAO). " 09/01/2023 - "l-borneol promotes neurovascular unit protection in the subacute phase of transient middle cerebral artery occlusion rats: p38-MAPK pathway activation, anti-inflammatory, and anti-apoptotic effect." 01/01/2017 - "Borneol was given to mice by gavage 3 days before middle cerebral artery occlusion (MCAO) induction until the day when the mice were sacrificed. " 08/01/2019 - "A metabolomics study approach based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) combined with a pathological study has been applied to study the metabolic disturbances of cerebral ischemia and evaluate the efficacies of Sal B and Sal B/borneol against cerebral ischemia in middle cerebral artery occlusion (MCAO) rats. " 11/04/2022 - "Methods This study aimed to screen the optimum proportion that natural borneol promotes formononetin entry into the brain, evaluate the anti-cerebral ischaemia efficacy of formononetin/natural borneol combination in middle cerebral artery occlusion/reperfusion model rats, and clarify the possible mechanism for natural borneol's promoting formononetin delivery in the brain. "
5.	Seizures (Absence Seizure) 08/01/2023 - "Meanwhile, (+)-borneol administration retarded kindling-induced epileptogenesis and relieved fully kindled seizures. " 10/01/2018 - "Among the isolates, borneol, thymol, and eugenol exerted the strongest protection against seizures. " 12/01/2023 - "This study was aimed at determining the influence of isopimpinellin (ISOP-a coumarin) when administered either separately or in combination with borneol (BOR-a monoterpenoid), on the antiseizure potencies of four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA)) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures. " 01/11/2023 - "The aim of this study was to determine the anticonvulsant profiles of scoparone (a simple coumarin) and borneol (a bicyclic monoterpenoid) when administered separately and in combination, as well as their impact on the antiseizure effects of four classic ASMs (carbamazepine, phenytoin, phenobarbital and valproate) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures. "

Related Drugs and Biologics

1.	tetramethylpyrazine
2.	Terpenes (Terpenoids)
3.	musk
4.	Edaravone
5.	Thymidine Monophosphate (TMP)
6.	Caspase 3 (Caspase-3)
7.	Therapeutic Uses
8.	Analgesics (Analgesic Drugs)
9.	Lipopolysaccharides
10.	fenchone

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Therapeutics
3.	Oral Administration
4.	Spinal Injections
5.	Drug Therapy (Chemotherapy)