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HI 6 (H16)

Also Known As:

H16; ((2-hydroxyiminomethylpyridiniummethyl)-(4'- carbamoylpyridiniummethyl))ether dichloride; 1-(((4-(aminocarbonyl)pyridino)methoxy)methyl)-2-((hydroxyimino)methyl)pyridinium dichloride; 1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane; HI-6; som-sim

Networked: 201 relevant articles (60 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kassa, Jiri: 18 articles (03/2015 - 07/2005)
2.	Kuca, Kamil: 18 articles (07/2013 - 01/2004)
3.	Jun, Daniel: 11 articles (07/2013 - 07/2005)
4.	Aas, Pål: 6 articles (09/2015 - 06/2005)
5.	Musilek, Kamil: 6 articles (03/2015 - 12/2008)
6.	Karasova, Jana Zdarova: 6 articles (07/2013 - 03/2009)
7.	Karasova, Jana: 6 articles (01/2009 - 01/2007)
8.	Kassa, J: 6 articles (08/2004 - 11/2000)
9.	Myhrer, Trond: 5 articles (09/2015 - 02/2006)
10.	Enger, Siri: 5 articles (09/2015 - 02/2006)

Related Diseases

1.	Poisoning 01/01/2006 - "The article also discusses the possibility of successful therapy with HI-6 against poisoning in humans relative to doses used in non-human primates and relative to its ability to reactivate inhibited human AChE." 08/22/1997 - "Efficacy of Jielin Injection, the 2-PAM-containing antidote used successfully in China for the treatment of organophosphate pesticide poisoning, was also evaluated and compared with HI-6 against single and combined poisonings. " 07/01/1995 - "The pharmacokinetics, safety, and apparent efficacy of HI-6 suggest it may be a superior oxime antidote against nerve agent poisoning." 07/29/2011 - "HI-6 has been safely used in individuals to treat OP insecticide poisoning, as well as in human volunteers, although its efficacy against OP nerve agent poisoning in humans cannot be demonstrated due to ethical considerations. " 12/01/1994 - "Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning."
2.	Seizures (Seizure) 07/01/2014 - "In the present study, rats were exposed to 1.2 LD50 GD or saline, treated with atropine sulfate (2mg/kg, im) and HI-6 (93.6mg/kg, im) 1min after GD exposure, and monitored for seizure activity. " 12/01/2011 - "In a subsequent experiment, rats were pretreated with HI-6 (125 mg/kg) to enhance survival and treatment started 40 min following seizure onset of a soman dose of 1.6 × LD(50). " 11/28/2004 - "In comparison, 1-[([4-(aminocarbonyl)pyridinio]methoxy)methyl]-2-[(hydroxyimino)methyl]pyridinium (HI-6, 125 mg/kg) was administered intraperitoneally 30 min prior to the soman challenge in control groups to reduce mortality of rats without affecting convulsions. " 11/28/2004 - "Soman induced profound limbic convulsions and 30% mortality, leading to increased blood-brain barrier permeability, neural injuries, learning and memory impairments, and physical incapacitation of survived rats pretreated with HI-6. " 01/01/2002 - "A high dose (100 μg/kg, 1.3×LD(50)) of soman induced severe epileptiform seizures in rats pretreated with HI-6 (125 mg/kg), resulting in brain injuries in discrete brain regions under histopathological examination in 24 h. "
3.	Influenza in Birds (Avian Flu) 11/01/2014 - "Despite extended wild bird monitoring studies over the past decade in many Eurasian countries and investigating hundreds of thousands of wild bird samples, no mallard duck was found to be positive for avian influenza virus of subtype H16 in faecal, cloacal or oropharyngeal samples. " 01/01/2015 - "However, the seroprevalence of one of the gull-specific subtypes of avian influenza (H16) was associated to the migratory strategy, with lower prevalence among the long-distance migrants, suggesting that migration may play a role in disease dynamics of certain pathogens at the population level. " 01/01/2013 - "Gulls are the primary hosts of H13 and H16 avian influenza viruses (AIVs). " 12/01/2012 - "Here, the crystal structures of H16 (a low-pathogenicity avian influenza virus) in their HA0 form (H16HA0) have been solved at 1.7-Å and 2.0-Å resolutions. " 01/01/2008 - "As a result of an US interagency avian influenza surveillance effort in wild birds, four isolates of influenza A viruses were initially identified as H7 by hemagglutination inhibition (HI) but subsequently identified as H16 through genetic sequence analysis. "
4.	Infection 11/15/2015 - "In this study, we investigated the effect of H13 and H16 LPAIV infection in black-headed gulls on susceptibility and virus excretion of subsequent infection with the same or the other virus within the same breeding season and between breeding seasons. " 12/01/2015 - "By targeting an important structural and conformational epitope, H16.U4 may identify subtle conformational changes in different maturation stages of the HPV capsid and provide a key probe to analyze the mechanisms of HPV uptake during the early stages of virus infection. " 11/15/2015 - "These results imply that the epidemiological cycles of H13 and H16 in black-headed gulls are relatively independent from each other and depend mainly on infection of first-year birds. " 11/15/2015 - "Reinfection with the same virus resulted in progressively less virus excretion, with complete abrogation of virus excretion after two infections for H13 but not H16. " 11/01/2014 - "Here, we tested the hypothesis that mallards are less permissive to infection with H16 viruses. "
5.	Body Weight (Weight, Body) 05/01/1994 - "The allometric exponent denoting the proportionality of body clearance of HI-6 to body weight of the 7 species studied was 0.76, which may be related to the renal excretion process for the drug. " 12/01/2013 - "In this study, Wistar rats were exposed to SM in doses of 0-40 mg/kg body weight and treated with the compound HI-6. " 07/04/2013 - "Doses of HI-6 salts corresponded with standard HI-6 dichloride dose in one autoinjector (500 mg) and were recalculated for 1 kg of body weight. " 01/01/2013 - "Doses of the HI-6 salts corresponded with a standard HI-6 dichloride dose in one autoinjector (500 mg) and were recalculated for one kilogram of body weight. " 04/01/2002 - "TCP and its adamantyl derivatives were administered intraperitoneally (2.5 mg/kg body weight) together with atropine (10.0 mg/kg body weight) and with or without 1/4 LD50 of the oxime HI-6. "

Related Drugs and Biologics

1.	Obidoxime Chloride (Obidoxime)
2.	Soman
3.	Atropine (Hyoscyamine)
4.	Oximes
5.	tabun
6.	Sarin
7.	Acetylcholinesterase
8.	pralidoxime (Protopam Chloride)
9.	cyclohexyl methylphosphonofluoridate (cyclosarin)
10.	VX (EDIM)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Intramuscular Injections
3.	Electrodes (Electrode)
4.	Drug Therapy (Chemotherapy)
5.	Topical Administration