bufalin

cardiotonic; powerful anesthetic & one of the active constituents of the Chinese drug ch'an su(senso); in Japan prepared from skin of Bufo bufo garfarizans; RN given refers to (3beta,5beta)-isomer

Also Known As:

Networked: 307 relevant articles (26 outcomes, 132 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Jing-Gung: 16 articles (03/2022 - 01/2012)
2.	Yin, Peihao: 12 articles (08/2022 - 01/2012)
3.	Liu, Yunpeng: 11 articles (01/2016 - 01/2009)
4.	Liu, Xuan: 9 articles (03/2018 - 01/2012)
5.	Tian, Xin: 8 articles (10/2022 - 04/2006)
6.	Qu, Xiujuan: 8 articles (01/2021 - 01/2009)
7.	Meng, Zhiqiang: 7 articles (06/2022 - 03/2011)
8.	Xu, Ke: 7 articles (10/2021 - 07/2017)
9.	Yuan, Zeting: 6 articles (08/2022 - 01/2018)
10.	Qiu, Yanyan: 6 articles (10/2021 - 09/2017)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2021 - "The present study suggested that the combination of bufalin and hydroxycampothecin improved the inhibitory effects of both drugs on CRPC tumors in vivo, potentially via the regulation of the PI3K/AKT/GSK-3β and p53-dependent apoptosis signaling pathways." 11/01/2022 - "Bufalin has potent activity against many tumors, but studies of its effect on CRC stemness are limited. " 01/01/2022 - "In this study, we showed that bufalin can function as an antitumor immune modulator that governs the polarization of TIMs from tumor-promoting M2 toward tumor-inhibitory M1, which induces HCC suppression through the activation of effector T cell immune response. " 01/01/2021 - "The present study shows that the anti-tumor effect of Bufalin mainly inhibit proliferation, extracellular matrix degradation and angiogenesis of HCC by influencing autophagy. " 03/29/2019 - "Previous studies revealed that bufalin exerted inhibitory effects on a variety of tumor cells. "
2.	Colonic Neoplasms (Colon Cancer) 07/01/2019 - "This study was conducted to investigate the role of bufalin in other colon cancer HCT-116 and SW620 cells as well as its potential mechanism. " 07/01/2019 - "Our previous study demonstrated that bufalin induced cell death via autophagy in HT-29 and Caco-2 colon cancer cells, but the action of bufalin remains unclear. " 07/01/2019 - "The effect of bufalin in HCT-116 and SW620 colon cancer cells was detected by assessing cell viability and cell death. " 10/30/2012 - "Bufalin not only inhibited the growth of colon cancer SW620 cells, but also induced apoptosis of SW620 cells. " 10/30/2012 - "The purpose of the research is to investigate the roles of Jak-STAT3 signaling pathway in bufalin-induced apoptosis in colon cancer SW620 cells. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2016 - "Our preliminary study indicated that bufalin could restrain the proliferation of human hepatoma BEL-7402 cells in a time- and dose-dependent manner. " 01/01/2014 - "In the current study, we investigated the effect of bufalin on the proliferation of the human hepatocellular carcinoma (HCC) cell lines, Huh-7 and HepG-2, and explored the therapeutic potential of the drug. " 07/01/2013 - "In this study, we aimed to investigate the efficacy and mechanism of bufalin in Huh7, Hep3B and HA22T human hepatoma cells. " 10/01/2012 - "In the present study, we investigated the pharmacological mechanisms of cell cycle arrest and autophagic cell death induced by bufalin in SK-HEP-1 human hepatocellular carcinoma cells in vitro. " 01/01/2022 - "The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma."
4.	Leukemia 09/01/2018 - "This study investigated whether bufalin affected immune responses of mice with WEHI-3 cell-generated leukemia in vivo. " 07/01/2000 - "To study the mechanism of bufalin on human leukemia cell inhibition. " 12/01/1995 - "The aim of this study was to explore an endogenous bufalin-like factor that induces leukemia cell differentiation. " 08/01/1995 - "In the present study, we found that bufalin at concentrations of 10(-7) M and higher induced apoptosis in human leukemia cells, such as HL60, ML1, but not in mouse leukemia M1 cells. " 09/01/2018 - "Bufalin increased immune responses by enhancing phagocytosis in mice with leukemia mice."
5.	Neoplasm Metastasis (Metastasis) 09/01/2019 - "Taken together, this is the first study revealing that HOTAIR promotes PCa bone metastasis, and bufalin may be a promising candidate for the treatment of this disease." 01/01/2016 - "In the present study, the colony formation assay, the Transwell invasion assay, the western blot analysis and the immunofluorescence method were respectively used to investigate the effect and mechanism of bufalin against HCC cell invasion and metastasis. " 10/01/2023 - "Our results show that bufalin targeting BFAR inhibits the occurrence and metastasis of GC through PI3K/AKT/mTOR signal pathway. " 01/01/2023 - "Overexpression of STAT3 attenuated the inhibitory function of bufalin on invasion and metastasis. " 01/01/2023 - "Bufalin reversed CAF-mediated CRC invasion and metastasis by inhibiting the STAT3 pathway. "

Related Drugs and Biologics

1.	chan su (ChanSu)
2.	Proteins (Proteins, Gene)
3.	Steroids
4.	huachansu
5.	Chitosan
6.	Amphibian Venoms
7.	Micelles
8.	Folic Acid (Vitamin M)
9.	Gemcitabine
10.	Oligosaccharides

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Nanospheres
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Drug Therapy (Chemotherapy)