thiopurine methyltransferase (thiopurine S-methyltransferase)

07/01/2005 - "The present study was undertaken to investigate the possible effects of various agents on thiopurine methyltransferase (TPMT) activity in red blood cells (RBCs) from patients with chronic inflammatory bowel disease (IBD). "
05/01/2005 - "Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease."
03/28/2014 - "Thiopurine-methyltransferase variants in inflammatory bowel disease: prevalence and toxicity in Brazilian patients."
01/01/2013 - "Thiopurine S-Methyltransferase gene polymorphisms in a healthy Slovak population and pediatric patients with inflammatory bowel disease."
01/01/2013 - "The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease."

12/01/2013 - "This study was conducted to investigate the thiopurine S-methyltransferase TPMT activity distribution and gene mutations in Tunisian population with positive diagnostic for Crohn's disease. "
12/01/2013 - "Analysis of thiopurine S-methyltransferase phenotype-genotype in a Tunisian population with Crohn's disease."
01/01/2003 - "Thiopurine methyltransferase genotype distribution in patients with Crohn's disease."
02/01/2009 - "Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression."
01/01/2003 - "Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine."

01/01/2006 - "The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions. "
01/01/2013 - "Polymorphisms in thiopurine S-methyltransferase (TPMT) gene have been associated with adverse drug reactions (ADRs) to AZA. "
07/01/2011 - "Low thiopurine S-methyltransferase (TPMT) enzyme activity is associated with increased thiopurine drug toxicity, particularly myelotoxicity. "
09/01/2007 - "We describe an entirely microchip-based method to genotype for common single nucleotide polymorphisms in the thiopurine S-methyltransferase gene that lead to serious adverse drug reactions for patients undergoing thiopurine therapy. "
09/01/2007 - "Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events."

03/11/2006 - "We aimed to assess the safety and efficacy of azathioprine as systemic monotherapy for moderate-to-severe atopic eczema, and the therapeutic importance of the thiopurine methyltransferase (TPMT) polymorphism (a key determinant of azathioprine-induced myelotoxicity) by using TPMT enzyme activity to establish azathioprine dose. "
06/01/2010 - "In this study, we evaluated the toxicity of azathioprine treatment adjusted to thiopurine methyltransferase activity in children with severe atopic dermatitis. "
03/11/2006 - "Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial."
01/01/2011 - "Life threatening myelotoxicity secondary to azathioprine in a patient with atopic eczema and normal thiopurine methyltransferase activity."
06/01/2010 - "Our experience shows that, when adjusted to thiopurine methyltransferase activity, azathioprine is a safe drug for the treatment of children with severe atopic dermatitis. "

12/01/2003 - "For the purpose of clarifying the influence of thiopurine methyltransferase (TPMT) gene single nucleotide polymorphisms (SNPs) on the efficacy of thiopurines and risk for its toxicity and therefore improving the safety and efficacy of thiopurines, the authors investigated TPMT genotype in acute leukemia in children who were intolerant to the treatment with 6-mercap topurine (6-MP). "
12/05/2014 - "Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy."
11/15/2013 - "Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells."
08/01/2006 - "Genotyping of thiopurine methyltransferase in patients with acute leukemia using LightCycler PCR."
12/01/2003 - "[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia]."