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thioesterase II
hydrolyzes the thioester bond linking the growing acyl chain to the 4'-phosphopantetheine of fatty acid synthetase complex, while acyl moiety is not yet a long chain
Also Known As:
medium chain thioesterase
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Oxidoreductases: 13671
Alcohol Oxidoreductases: 56
NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
3-Oxoacyl-(Acyl-Carrier-Protein) Reductase: 2
Fatty Acid Synthases: 1317
thioesterase II: 4
Transferases: 6589
Acyltransferases: 374
Acetyltransferases: 1040
Acyl-Carrier Protein S-Acetyltransferase
Fatty Acid Synthases: 1317
thioesterase II: 4
Acyl-Carrier Protein S-Malonyltransferase
Fatty Acid Synthases: 1317
thioesterase II: 4
Hydrolases: 2166
Esterases: 1574
Thiolester Hydrolases
Fatty Acid Synthases: 1317
thioesterase II: 4
thioesterase II: 4
Lyases: 637
Carbon-Oxygen Lyases
Hydro-Lyases: 266
Fatty Acid Synthases: 1317
thioesterase II: 4
Related Diseases
1.
Starvation
05/01/1994 - "
coli thioesterase II fully relieved the inhibition of fatty acid synthesis seen upon glycerol starvation, whereas overexpression of ACP had no effect.
"
2.
Neoplasms (Cancer)
09/01/1986 - "
Of 51 rats transplanted with the R3230AC tumor, 37 showed elevated serum thioesterase II levels; of 40 transplanted with the DMBA 1 tumor, 35 showed elevated serum thioesterase II. Furthermore, there was a statistically significant correlation between serum thioesterase II and tumor burden in both tumor model systems.
"
09/01/1986 - "
During this period the transplanted tumor established a new network of blood vessels; no thioesterase II was detectable in the serum.
"
09/01/1986 - "
Immunoreactive thioesterase II was detected in all of the epithelial derived mammary tumors tested, being highest in tumors that exhibited obvious epithelial morphology.
"
08/01/1984 - "
These findings raise the possibility that thioesterase II may be of use as a diagnostic tool to identify human tumors of breast epithelial origin.
"
09/01/1986 - "
Subsequently, thioesterase II levels in the tumors returned to the values observed before transplantation and thioesterase II was detectable in the serum.
"
3.
Carcinoma (Carcinomatosis)
08/01/1984 - "
Thus thioesterase II was detected immunohistochemically in normal human breast epithelia derived from both lactating and nonlactating breast tissue, in cultured cells derived from both primary breast epithelial tumors and from a metastatic tumor of breast origin, and in several human breast epithelial cell lines; the enzyme could not be detected in HeLa cells, in a colon carcinoma, or in a mammary myoepithelial cell line.
"
4.
Breast Neoplasms (Breast Cancer)
09/01/1986 - "
These results indicate that thioesterase II may be a useful serum marker for mammary cancer.
"
09/01/1986 - "
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
"
5.
Adenocarcinoma
05/28/1980 - "
The ability or inability of certain rodent mammary adenocarcinomas to synthesize medium chain fatty acids in vitro, correlates with the presence or absence of the specific mammary chain-terminating enzyme, thioesterase II.
"
Related Drugs and Biologics
1.
Fatty Acids (Saturated Fatty Acids)
2.
Glycerol (Glycerine)
3.
Enzymes
4.
Biomarkers (Surrogate Marker)
Related Therapies and Procedures
1.
Transplantation