thiamin pyridinylase

05/01/2010 - "We purified recombinant Bacillus thiaminolyticus thiaminase I enzyme, which digests thiamine, to study acute thiamine starvation in breast cancer. "

05/01/2010 - "In summary, thiaminase I is cytotoxic in breast cancer cell lines and triggers the unfolded protein response. "
05/01/2010 - "Sensitivity of breast cancer cell lines to recombinant thiaminase I."
05/01/2010 - "These findings suggest that THTR2 down-regulation in breast tumors may present a nutritional vulnerability that could be exploited by thiaminase I enzyme therapy."
05/01/2010 - "We purified recombinant Bacillus thiaminolyticus thiaminase I enzyme, which digests thiamine, to study acute thiamine starvation in breast cancer. "
05/01/2010 - "Thiaminase I enzyme was cytotoxic in six breast cancer cell lines with IC(50)s ranging from 0.012 to 0.022 U/ml. The growth inhibitory effects of the combination of thiaminase I with either doxorubicin or paclitaxel were also examined. "

01/01/2023 - "Dietary factors potentially impacting thiaminase I-mediated thiamine deficiency."
12/01/2009 - "Dietary thiaminase I is a cause of thiamine deficiency in animals. "
01/01/2018 - "The enzyme is only known to be produced by a small subset of microorganisms, although thiaminase I activity has been associated with numerous plants and animals, and is implicated in thiamine deficiencies brought on by consumption of organisms containing this enzyme. "
01/01/2018 - "Thiaminases degrade thiamine by catalyzing the base-exchange substitution of thiazole with a nucleophile, and thiaminase I specifically has been implicated in thiamine deficiency syndromes in animals. "

09/01/2011 - "To investigate a strategy to exploit abnormal cancer-associated metabolism related to thiamine, we tested the cytotoxicity of native Bacillus thiaminolyticus thiaminase I enzyme, which digests thiamine, in the NCI60 cell line drug cytotoxicity screening program and found that leukemia cell lines were among the most sensitive to thiaminase I. We obtained additional lymphoid leukemia cell lines and confirmed that native thiaminase I and linear chain PEGylated thiaminase I enzyme (LCPTE) have cytotoxic activity in these cell lines. "

11/21/1970 - "Thiaminase I in the development of cerebrocortical necrosis in sheep and cattle."