superoxide-forming enzyme

catalyzes the reduction of oxygen to superoxide with NADPH as the electron donor, then undergoes a secondary reaction which leads to the production of hydrogen peroxide, OH and perhaps other reactive oxidants

Also Known As:

Networked: 38 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Mitsushita, Junji: 2 articles (03/2009 - 05/2004)
2.	Kamata, Tohru: 2 articles (03/2009 - 05/2004)
3.	Mohajerani, Seyed Amir: 1 article (02/2013)
4.	Velayati, Ali Akbar: 1 article (02/2013)
5.	Mahdaviani, Seyed Alireza: 1 article (02/2013)
6.	Rezaei, Nima: 1 article (02/2013)
7.	Casanova, Jean-Laurent: 1 article (02/2013)
8.	Mansouri, Seyed Davood: 1 article (02/2013)
9.	Harberd, Nicholas P: 1 article (11/2012)
10.	Ragoussis, Jiannis: 1 article (11/2012)

Related Diseases

1.	Chronic Granulomatous Disease 02/01/2013 - "Chronic granulomatous disease (CGD) is an inherited disorder, characterized by defects in superoxide-generating NADPH oxidase of phagocytes. " 05/01/2000 - "Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder which results from absence or malfunction of the respiratory burst oxidase normally expressed in neutrophils and other phagocytic leukocytes. " 06/01/1998 - "X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase." 01/01/1993 - "The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease." 08/01/1991 - "The respiratory burst oxidase and the molecular basis of chronic granulomatous disease."
2.	Leukemia 12/01/1998 - "We have used a human leukemia cell line that, after homologous recombination knockout of the gp91-phox subunit of the phagocyte respiratory-burst oxidase cytochrome b-558, mimics chronic granulomatous disease (X-CGD) to study the role of oxygen radicals in apoptosis. "
3.	Infection 11/01/2004 - "Patients with CGD are predisposed to recurrent bacterial and fungal infections because the superoxide-generating NADPH oxidase activity is needed for efficient killing of microbes. " 05/01/1991 - "The neutrophil response to infection and inflammation includes membrane fusion or degranulation and activation of the membranous respiratory burst oxidase. " 01/01/1999 - "Abrogation of the phagocyte respiratory burst oxidase during experimental infection with zwf mutant Salmonella causes a prompt restoration of virulence, while inhibition of inducible nitric oxide synthase results in delayed lethality. " 02/01/1995 - "Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective phagocyte respiratory burst oxidase, life-threatening pyogenic infections and inflammatory granulomas. " 10/01/2008 - "Resistance against infections ensues intracellularly following initial phagocytosis of microorganisms with the oxygen-dependent respiratory burst, the key enzyme of which is the respiratory burst oxidase, whereby oxygen radicals are produced for microbial destruction. "
4.	Neoplasms (Cancer) 05/15/2010 - "Here, to further investigate the role of HIPK2 in p53 activation, we started with the finding that HIPK2 inhibition upregulated Nox1, a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase, involved in tumor progression and ROS production. " 12/01/2005 - "Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors." 05/15/2004 - "Here, we report that Ras oncogene up-regulates the expression of Nox1, a homologue of the catalytic subunit of the superoxide-generating NADPH oxidase, via the mitogen-activated protein kinase kinase-mitogen-activated protein kinase pathway, and that small interfering RNAs designed to target Nox1 mRNA effectively blocks the Ras transformed phenotypes including anchorage-independent growth, morphological changes, and production of tumors in athymic mice. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/01/2005 - "Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease."

Related Drugs and Biologics

1.	cytochrome b558
2.	Proteins (Proteins, Gene)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Oxidoreductases
5.	NADP (NADPH)
6.	Cytochromes b (Cytochrome b)
7.	NADPH Oxidase (NAD(P)H oxidase)
8.	neutrophil cytosol factor 67K
9.	Oxygen
10.	Cytochromes