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ribonuclease T(2)

also called ribonuclease II, but do not confuse with the exoribonuclease EC 3.1.13.1
Also Known As:
Bacillus intermedius 7p ribonuclease; Bacillus intermedius ribonuclease; Bacillus intermedius secreted ribonuclease; E coli RNase I; RNase I, E coli; RNase T2; binase; binase II; ribonuclease T2
Networked: 50 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ilinskaya, Olga: 9 articles (12/2020 - 10/2011)
2. Ulyanova, Vera: 8 articles (12/2020 - 10/2011)
3. Ilinskaya, Olga N: 6 articles (11/2020 - 10/2007)
4. Zelenikhin, P V: 6 articles (01/2020 - 05/2005)
5. Mitkevich, Vladimir A: 5 articles (11/2020 - 10/2007)
6. Ilinskaya, O N: 5 articles (01/2020 - 10/2013)
7. Zelenikhin, Pavel: 4 articles (01/2019 - 07/2013)
8. Makarov, Alexander A: 4 articles (09/2017 - 10/2007)
9. Kolpakov, A I: 4 articles (01/2017 - 05/2005)
10. Dudkina, Elena: 3 articles (12/2020 - 01/2018)

Related Diseases

1. Neoplasms (Cancer)
2. Neoplasm Metastasis (Metastasis)
11/02/2020 - "Intraperitoneal injections of binase in RLS40-bearing mice resulted in the retardation of primary tumour growth by up to 60% and inhibition of metastasis in the liver by up to 86%, with a decrease in reactive inflammatory infiltration and mitosis in tumour tissue. "
06/01/2014 - "Binase at doses of 0.1-1 mg/kg which produced effective suppression of tumor growth and metastasis, showed positive effect on the liver of tumor-bearing mice expressed in a significant reduction in the volume of destructive changes in the liver parenchyma and return to the normal level of the liver regenerative potential impaired due to endogenous intoxication and tumor burden."
07/01/2013 - "Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells."
07/01/2013 - "We show for the first time that intraperitoneal injection of binase at a dose range 0.1-5 mg/kg results in retardation of primary tumor growth up to 45% in LLC and RLS 40 and inhibits metastasis up to 50% in LLC and RLS 40 and up to 70% in B-16 melanoma. "
05/01/2018 - "A number of these target genes have been demonstrated to be directly involved in tumor metastasis (including MYC proto-oncogene, bHLH transcription factor, high-mobility group AT-Hook 2, peptidase inhibitor 3, KIT proto-oncogene receptor tyrosine kinase, Jun proto-oncogene, AP-1 transcription factor subunit and ribonuclease T2), or have physiological associations to immunity (including C-C motif chemokine receptor 4 and cluster of differentiation 40 ligand) and cellular metabolism (including peroxisome proliferator-activated receptor γ, coactivator 1 α). "
3. Ovarian Neoplasms (Ovarian Cancer)
4. Adenocarcinoma of Lung
5. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Related Drugs and Biologics

1. Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
2. Ribonucleases (Ribonuclease)
3. Bacillus pumilus ribonuclease
4. Interferons
5. Bleomycin (Blenoxane)
6. Anti-Bacterial Agents (Antibiotics)
7. Proteins (Proteins, Gene)
8. Phosphates (Orthophosphate)
9. Enzymes
10. ribonuclease T(2)

Related Therapies and Procedures

1. Therapeutics
2. Intraperitoneal Injections