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quinolinic acid synthetase

aspartic acid & dihydroxyacetone phosphate are substrates; FAD is cofactor

Also Known As:

quinolinate synthetase; Synthetase, quinolinate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - quinolinic acid synthetase: 2
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Multienzyme Complexes: 8
    - quinolinic acid synthetase: 2

Related Diseases

1.	Hyperoxia 01/01/1991 - "The ability of niacin to relieve the growth-inhibiting effect of hyperoxia on Escherichia coli can be attributed to the dioxygen sensitivity of quinolinate synthetase. "
2.	Poisoning 12/01/1992 - "Protein A of quinolinate synthetase is the site of oxygen poisoning of pyridine nucleotide coenzyme synthesis in Escherichia coli."
3.	Dehydration (Water Stress) 01/01/1991 - "This sequence, together with the effect of the Fe(II)-chelating agents, suggests that the O2-sensitive site of quinolinate synthetase is an iron-sulfur cluster which is essential for the dehydration reaction catalyzed by the A protein."

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Sulfur
3.	Staphylococcal Protein A (Protein A)
4.	Proteins (Proteins, Gene)
5.	Nucleotides
6.	Niacin (Nicotinic Acid)
7.	Iron
8.	Coenzymes (Enzyme Cofactors)
9.	Chelating Agents
10.	pyridine