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thimet oligopeptidase (endo-oligopeptidase)

Subscribe to New Research on thimet oligopeptidase

endo-oligopeptidase was EC 3.4.22.19 1989-1992; Cl-peptidase was EC 3.4.99.31 1978-1992; thiol-dependent metalloproteinase which cleaves bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates with 5-15 residues

Also Known As:

endo-oligopeptidase; tissue-endopeptidase degrading collagenase-synthetic substrate; Cl-peptidase; PZ-peptidase; PZ-peptidase A; PZ-peptidase B; endo-oligopeptidase A; endooligopeptidase A; endopeptidase 22.19; endopeptidase 24.15; endopeptidase 3.4.24.15; endopeptidase A; enkephalin-converting enzyme; metalloendopeptidase 24.15; metalloendopeptidase M78; proenkephalin converting enzyme; soluble metallo-endopeptidase; thimet peptidase; zinc endopeptidase 24-15

Networked: 22 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Metalloproteases: 2318
        Metalloendopeptidases: 49
        thimet oligopeptidase: 22
      - Endopeptidases: 212
        Metalloendopeptidases: 49
        thimet oligopeptidase: 22

Experts

1.	Yacubian, Elza Márcia Targas: 1 article (05/2014)
2.	Perosa, Sandra Regina: 1 article (05/2014)
3.	Carrete, Henrique: 1 article (05/2014)
4.	Simões, Priscila Santos Rodrigues: 1 article (05/2014)
5.	Canzian, Mauro: 1 article (05/2014)
6.	Mazzacoratti, Maria da Graça Naffah: 1 article (05/2014)
7.	Chagas, Jair Ribeiro: 1 article (05/2014)
8.	Maurer Morelli, Claudia Vianna: 1 article (05/2014)
9.	Lopes-Cendes, Iscia: 1 article (05/2014)
10.	Tufik, Sergio: 1 article (05/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2010 - "This study aims to find autophagy-related cysteine endopeptidase A (APG4A) which has a significant role in suppressing various cancers. " 02/15/2008 - "Neprilysin and/or thimet oligopeptidase are expressed in all experimental human tumor types thus far tested as well as in a large majority of human breast and prostate tumor biopsies. " 02/15/2008 - "Neprilysin and thimet oligopeptidase expression, two enzymatic activators of DTS-201, was also characterized in human breast and prostate tumor biopsies. " 01/01/2007 - "Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth." 01/01/2007 - "Thimet oligopeptidase (TOP) and neurolysin activities were then investigated in B16F10-Nex2 melanoma cells aiming at gene sequencing, enzyme distribution and activity, influence on tumor development, substrate specificity, hydrolytic products and susceptibility to inhibitors. "
2.	Fibrosis (Cirrhosis) 05/30/1985 - "Since circulating inhibitors and activators of the PZ-peptidase activity can be excluded, as proved by this study, joint peptide and PZ-peptidase serum measurements would seem to offer a simple reliable non-invasive method for differentiating and monitoring progressive and non-progressive forms of hepatic fibrosis." 05/30/1985 - "However, the greater increase in PZ-peptidase than in peptide serum levels seen in some patients seems to indicate a minor tendency to progressive fibrosis or a trend towards resolution. " 05/30/1985 - "Unlike liver disease patients, normal peptide and PZ-peptidase levels were found in patients with pancreatic fibrosis. " 05/30/1985 - "The increase in collagen synthesis without a parallel increase in collagen degradation seen in chronic active hepatitis could be regarded as a sign of impending cirrhosis, whereas the unbalanced rise in PZ-peptidase observed in chronic persistent hepatitis is consistent with the non-progressive character of this disorder. " 05/30/1985 - "To obtain a dynamic and non-invasive picture of hepatic fibrosis in pre-cirrhotic liver diseases we measured both the concentration of the N-terminal peptide of procollagen III, as a marker of collagen synthesis, and the activity of PZ-peptidase, an enzyme involved in collagen degradation, in the serum of alcoholic or chronic viral hepatitis patients. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2014 - "The study was designed to detect the expression level of thimet oligopeptidase (THOP1) protein in non-small cell lung cancer (NSCLC) and investigate its correlation with clinicopathologic features and prognosis. "
4.	Osteoarthritis 03/01/1993 - "CL-peptidase and PEP activity significantly higher in C57BL/6S mice than in osteoarthrosis-free C57BL/6N and ddY mice. " 12/01/1987 - "The CL-peptidase activity in synovial fluid was significantly higher in patients with rheumatoid arthritis (RA) than in patients with osteoarthritis (OA) and in arthropathy-free controls. " 03/01/1993 - "The histologic changes in the temporo mandibular joint (TMJ) and the activity of serum collagenase-like (CL) peptidase and prolyl endopeptidase (PEP) were compared in mice with spontaneous osteoarthrosis (C57 black mouse/6 Silverberg (C57BL/6S) and control mice (C57 black mouse/6N (C57BL/6N) and ddY). "
5.	Liver Diseases (Liver Disease) 05/30/1985 - "Unlike liver disease patients, normal peptide and PZ-peptidase levels were found in patients with pancreatic fibrosis. " 05/30/1985 - "Type III procollagen peptide and PZ-peptidase serum levels in pre-cirrhotic liver diseases." 02/28/1991 - "The concentration of the N-terminal peptide of procollagen III and the activity of collagen peptidase (PZ-peptidase) were measured in sera from 92 patients with chronic liver disease. " 05/30/1985 - "To obtain a dynamic and non-invasive picture of hepatic fibrosis in pre-cirrhotic liver diseases we measured both the concentration of the N-terminal peptide of procollagen III, as a marker of collagen synthesis, and the activity of PZ-peptidase, an enzyme involved in collagen degradation, in the serum of alcoholic or chronic viral hepatitis patients. "

Related Drugs and Biologics

1.	Cysteine (L-Cysteine)
2.	Collagenases (Collagenase)
3.	Procollagen
4.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
5.	neurolysin
6.	prolyl oligopeptidase (prolyl endopeptidase)
7.	Cathepsin G
8.	Metalloproteases (Metalloproteinases)
9.	Collagen Type III (Type III Collagen)
10.	Opioid Peptides (Opioid Peptide)