prothrombinase complex

03/01/1994 - "Our results demonstrate that direct inhibition of prothrombinase complex assembly is effective in arresting venous thrombosis."

01/01/1990 - "Our results indicate that these tumor cells can readily assemble a functional cell surface prothrombinase complex that may be important in fibrin deposition associated with the growth and metastatic progression of these, and perhaps, other tumors."
01/01/2005 - "However, few studies correlate this type of cancer with formation of the prothrombinase complex, which is responsible for conversion of prothrombin into thrombin in the coagulation system. "

01/01/2005 - "The aim of this study was to investigate the assembly and regulation of prothrombinase complex on the murine melanoma cell line, B16F10. "
01/01/2005 - "Assembly and regulation of prothrombinase complex on B16F10 melanoma cells."
01/01/2005 - "Our data demonstrate that B16F10 melanoma cells generate thrombin by promoting assembly of the prothrombinase complex. "
12/03/1990 - "While melanoma cells served as a suitable surface for prothrombinase complex formation, folate deficiency did not alter this membrane function, suggesting that the membrane changes associated with folate deficiency are relatively specific."

10/01/2014 - "The balance between bleeding and thrombosis depends on the amount of thrombin produced, and this in turn depends on the function of the prothrombinase complex. "
01/01/2013 - "Overt exposure of phosphatidylserine on surfaces of RBCs provide docking sites for formation of the prothrombinase complex, which further aids in amplification of coagulation leading to subsequent thrombosis. "
03/01/2002 - "Activation of the prothrombinase complex, which catalyzes the formation of thrombin from prothrombin, is crucial for the (patho)physiological processes of hemostasis and thrombosis. "
11/01/1997 - "A synergic interaction between the prothrombin 20210 GA genotype and the factor V Leiden mutation, both potentially affecting the prothrombinase complex, was suggested by the early onset of thrombosis (median age 22 years) in doubly heterozygous patients. "
12/30/2011 - "Darexaban and darexaban glucuronide inhibited the prothrombin activation induced by prothrombinase complex or whole blood clot with similar potency to free factor Xa. "

12/01/2011 - "By formation of a highly active membrane-bound prothrombinase complex, these PLTs represent an important step in the coagulation cascade as a consequence of their ability to generate thrombin at the site of vascular injury. "
12/08/2006 - "Incorporation of prothrombin into the prothrombinase complex is essential for rapid thrombin generation at sites of vascular injury. "