prostacyclin synthetase (prostacyclin synthase)

05/01/2002 - "Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats."
05/01/2010 - "Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats."
06/01/2004 - "Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension."
06/01/1999 - "Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension."
06/01/1999 - "Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension."

02/07/2015 - "Previous studies suggest that prostacyclin synthase (PGIS) expression and prostacyclin receptor (IP) activation are beneficial for treatment of acute traumatic and ischemic brain injury. "

09/01/2010 - "This devastating disease of the pulmonary vasculature is associated with vasoconstriction, thrombosis and proliferation, and this may be partly due to lack of endogenous prostacyclin secondary to prostacyclin synthase downregulation. "
01/01/1982 - "The inhibition of PGI2 synthetase results in an increase of platelet thrombosis induced by adenosine diphosphate. "
01/01/1980 - "The inhibition of PGI2 synthetase by 15-hydroxyarachidonic acid (15-HPAA) results in an enhancement of local thrombus formation."
01/01/1980 - "The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis."
01/01/1980 - "In an "in vivo" model we demonstrated that topical superfusion of the arterial segment with ASA, indomethacin or flurbiprofen results in a marked decrease of local white platelet thrombus formation while superfusion with PGI2 synthetase inhibitors results in thrombus enhancement. "

01/01/2015 - "Expression of Prostacyclin-Synthase in Human Breast Cancer: Negative Prognostic Factor and Protection against Cell Death In Vitro."
01/01/2015 - "To elucidate the significance of PGI2 in human breast cancer, we performed immunohistochemistry to analyze expression of prostacyclin-synthase (PGIS) in 248 human breast cancer specimens obtained from surgical pathology files. "
01/01/2012 - "CYP2W1, CYP4F11 and CYP8A1 polymorphisms and interaction of CYP2W1 genotypes with risk factors in Mexican women with breast cancer."
01/01/2016 - "Association of CYP8A1 (Prostacyclin I2 synthase) polymorphism rs5602 with breast cancer in Mexican woman."
06/15/1989 - "These data suggest that inhibition of prostacyclin synthetase, but not thromboxane synthetase, may present a useful mechanism for mammary cancer chemoprevention in animals consuming a diet high in fat. "

10/01/2009 - "The aim of this study was to assess the association between the human CYP8A1 gene and myocardial infarction (MI) in Chinese people. "
10/01/2009 - "Haplotype analysis of the CYP8A1 gene associated with myocardial infarction."
03/01/2009 - "[Association of GLu461ALa polymorphism of prostacyclin synthase gene with myocardial infarction in Uigur population]."
02/01/2009 - "[Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population]."
12/01/2008 - "To investigate the association between the polymorphism of the prostacyclin synthase gene and Uigur patients with myocardial infarction in Xinjiang. "