prostacyclin synthetase (prostacyclin synthase)

05/01/2002 - "Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats."
05/01/2010 - "Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats."
06/01/2004 - "Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension."
06/01/1999 - "We hypothesized that a decrease in expression of the critical enzyme PGI2 synthase (PGI2-S) in the lung may represent an important manifestation of pulmonary endothelial dysfunction in severe pulmonary hypertension (PH). "
06/01/1999 - "Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension."

01/01/2015 - "Previous studies suggest that prostacyclin synthase (PGIS) expression and prostacyclin receptor (IP) activation are beneficial for treatment of acute traumatic and ischemic brain injury. "

01/01/1980 - "The inhibition of PGI2 synthetase by 15-hydroxyarachidonic acid (15-HPAA) results in an enhancement of local thrombus formation."
09/01/2010 - "This devastating disease of the pulmonary vasculature is associated with vasoconstriction, thrombosis and proliferation, and this may be partly due to lack of endogenous prostacyclin secondary to prostacyclin synthase downregulation. "
01/01/1982 - "The inhibition of PGI2 synthetase results in an increase of platelet thrombosis induced by adenosine diphosphate. "
01/01/1980 - "The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis."
01/01/1980 - "In an "in vivo" model we demonstrated that topical superfusion of the arterial segment with ASA, indomethacin or flurbiprofen results in a marked decrease of local white platelet thrombus formation while superfusion with PGI2 synthetase inhibitors results in thrombus enhancement. "

01/01/2015 - "Expression of Prostacyclin-Synthase in Human Breast Cancer: Negative Prognostic Factor and Protection against Cell Death In Vitro."
01/01/2012 - "CYP2W1, CYP4F11 and CYP8A1 polymorphisms and interaction of CYP2W1 genotypes with risk factors in Mexican women with breast cancer."
01/01/2015 - "To elucidate the significance of PGI2 in human breast cancer, we performed immunohistochemistry to analyze expression of prostacyclin-synthase (PGIS) in 248 human breast cancer specimens obtained from surgical pathology files. "

01/01/2002 - "The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). "
01/01/2002 - "Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension."
11/30/1999 - "Human prostacyclin synthase gene and hypertension : the Suita Study."
07/01/2003 - "Haplotype analysis of the prostacyclin synthase gene and essential hypertension."
01/01/2003 - "Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension."