proline dipeptidase (prolidase)

01/01/2020 - "This study deeply elucidates a link between prolidase activity and neuronal maturation shedding new light on the molecular basis of functional aspects in the prolidase deficiency."
01/01/1994 - "Prolidase deficiency: biochemical study of erythrocyte and skin fibroblast prolidase activity in Italian patients."
01/01/1988 - "Biochemical studies on prolidase in sera from control, patients with prolidase deficiency and their mother."
03/01/1982 - "Biochemical studies on human prolidase (EC 3.4.13.9) and prolidase deficiency are described. "
04/01/2021 - "The importance of prolidase in human health is underlined by a rare hereditary syndrome referred to as Prolidase Deficiency. "

10/01/2012 - "The aim of this study is to measure prolidase activity as a marker of treatment and diagnosis in an experimental lung fibrosis animal model. "
01/01/2010 - "Several studies have shown increased prolidase activity in fibrosis, though controversy persists. "
12/01/2022 - "The relationship between serum prolidase activity, hidroxiprolyne and fibrosis (p<0.05). "
01/01/2022 - "We further show that decreased prolidase activity is coupled with increased systemic levels of PEPD that act as a pathogenic trigger of AT fibrosis and IR. "
06/14/2015 - "Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). "

01/01/2022 - "This study was conducted to investigate the proliferative capacity of recombinant human prolidase (rhPEPD) in a human model of inflammation induced by IL-1β in HaCaT keratinocytes. "
01/14/2023 - "The potential of recombinant human prolidase (rhPEPD) to induce wound healing in an experimental model of IL-1β-induced inflammation in human fibroblasts was studied. "
01/14/2023 - "Recombinant Human Prolidase (rhPEPD) Induces Wound Healing in Experimental Model of Inflammation through Activation of EGFR Signalling in Fibroblasts."
03/18/2022 - "In addition to the prolidase activity; SA levels might be associated with inflammation."
01/01/2022 - "Recombinant Prolidase Activates EGFR-Dependent Cell Growth in an Experimental Model of Inflammation in HaCaT Keratinocytes. "

01/01/2013 - "Serum prolidase activity in ankylosing spondylitis and rheumatoid arthritis."
11/01/2016 - "Serum prolidase level in ankylosing spondylitis: low serum levels as a new potential gold standard biomarker for disease activity."
01/01/2013 - "The aim of the present study was to emphasize the collagen turnover in 2 of the most common chronic inflammatory rheumatic diseases by evaluating serum prolidase activity (SPA) in ankylosing spondylitis (AS) and rheumatoid arthritis (RA). "

01/01/2016 - "The findings obtained in our study showed that prolidase activity increases directly proportionaly with the severity of pancreatitis. "
01/01/2016 - "The value of prolidase enzyme in rats with experimentally induced mild and severe pancreatitis."
11/01/2002 - "We investigated whether prolidase activity may reflect disturbances of collagen metabolism in human pancreatitis and pancreatic cancer. "
11/01/2002 - "In pancreatitis tissue, an increase in collagen content, collagenolytic activity and beta 1 integrin expression were accompanied by significant decrease (about 2-fold) in prolidase activity and marked decrease in its expression, compared to normal pancreas. "
01/01/2016 - "This study was performed to determine if prolidase enzyme, which plays a role in collagen metabolism, could be used as a parameter to assess the severity of pancreatitis in experimentally induced mild and severe pancreatitis. "