proelastase

precursor of EC 3.4.21.11, pancreatopeptidase

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Pancreatic Elastase: 3861
        proelastase: 8
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Pancreatic Elastase: 3861
        proelastase: 8
- Enzyme Precursors: 724
  - proelastase: 8
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protein Precursors: 37
    - Enzyme Precursors: 724
      - proelastase: 8

Related Diseases

1.	Pancreatitis 12/15/1970 - "[Behavior of proelastase in pancreatic tissue and juice in ethionine-induced pancreatitis of rats]." 09/01/1972 - "Assays of elastase in extracts of these pancreases showed no free enzyme, but varying amounts of proelastase.A review of autopsy findings in 33 patients with fatal liver necrosis attributed to halothane anesthesia, demonstrated changes of acute pancreatitis only in two. " 11/01/1997 - "To characterize the activation of pancreatic zymogens (trypsinogen, chymotrypsinogen, and proelastase 1) in acute pancreatitis, we studied the activation of pancreatic juice with porcine enteropeptidase in vitro, and then enzymatic activities and the generation of pancreatic stone protein (PSP) S1 form in pancreatic juice were investigated. "
2.	Neoplasms (Cancer) 12/01/1991 - "These data suggest that the stenosis or obstruction of the pancreatic duct by cancer probably liberates proelastase 1 from the normal pancreatic acinal cells into the blood. " 12/01/1991 - "The elution profile of all patients with pancreatic head cancer and one of seven patients with pancreatic body-tail cancer with a poststenotic dilatation of the main pancreatic duct showed two peaks: the first was eluted in the position of the alpha 1-AT-E1 complex, and the second was eluted between alpha 1-AT-E1 and elastase 1. The molecular weight of the IRE1 appearing specifically in patients with cancer of the pancreatic head was about 46,000 to 48,000, which was different from the 30,500 molecular weight of (pro)elastase 1. It is possible that proelastase 1 binding with an unknown substance exists in patients with pancreatic cancer. " 12/01/1982 - "We have previously established that secretory proteins from a rat acinar cell tumor lack two forms of procarboxypeptidase B, are deficient in a major lipase species, and possess markedly reduced amounts of the basic proteins proelastase, basic chymotrypsinogen, basic trypsinogen and ribonuclease (Iwanij, V., and J.D. " 12/01/1982 - "Our results indicate that a group of basic polypeptides including proelastase, basic trypsinogen, basic chymotrypsinogen, and ribonuclease, two out of three forms of procarboxypeptidase B, and the major lipase species were greatly reduced or absent in tumor cell secretion. "
3.	Necrosis 09/01/1976 - "The onset of the hemorrhagic necrosis of the pancreas is due to an endogenous intraparenchymal activation of the zymogenic proteases, including proelastase. " 09/01/1972 - "Assays of elastase in extracts of these pancreases showed no free enzyme, but varying amounts of proelastase.A review of autopsy findings in 33 patients with fatal liver necrosis attributed to halothane anesthesia, demonstrated changes of acute pancreatitis only in two. "
4.	Pneumonia (Pneumonitis) 01/01/1986 - "[Serum elastase, proelastase and free hydroxyproline in acute pneumonia]."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/1991 - "The elution profile of all patients with pancreatic head cancer and one of seven patients with pancreatic body-tail cancer with a poststenotic dilatation of the main pancreatic duct showed two peaks: the first was eluted in the position of the alpha 1-AT-E1 complex, and the second was eluted between alpha 1-AT-E1 and elastase 1. The molecular weight of the IRE1 appearing specifically in patients with cancer of the pancreatic head was about 46,000 to 48,000, which was different from the 30,500 molecular weight of (pro)elastase 1. It is possible that proelastase 1 binding with an unknown substance exists in patients with pancreatic cancer. "

Related Drugs and Biologics

1.	Trypsinogen
2.	Pancreatic Elastase (Elastase)
3.	Chymotrypsinogen
4.	Carboxypeptidase B
5.	Ribonucleases (Ribonuclease)
6.	Lipase (Acid Lipase)
7.	Lithostathine
8.	Proteins (Proteins, Gene)
9.	Peptides (Polypeptides)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Anesthesia