poly ADP-ribose glycohydrolase

splits ribose-ribose bonds; glycohydrolase I has a higher molecular weight and is tightly bound to mammalian cell nuclei; glycohydrolase II has lower molecular weight & is found in cytosol; inappropriate inhibitor SCR merged here to delete after cutover (SB); do not confuse with PARG1 protein, human

Also Known As:

Networked: 65 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Haiyan: 5 articles (03/2021 - 01/2015)
2.	Wang, Zhao-Qi: 5 articles (12/2010 - 03/2005)
3.	Cuzzocrea, Salvatore: 5 articles (01/2007 - 06/2004)
4.	Zhang, Jie: 4 articles (01/2007 - 06/2004)
5.	Wu, Desheng: 3 articles (03/2021 - 01/2015)
6.	Yuan, Jianhui: 3 articles (03/2021 - 01/2015)
7.	Zeng, Zhuoying: 3 articles (03/2021 - 10/2018)
8.	James, Dominic I: 3 articles (01/2020 - 01/2019)
9.	Smith, Kate M: 3 articles (01/2020 - 01/2019)
10.	Liu, Jianjun: 3 articles (01/2019 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Targeting poly(ADP-ribose) glycohydrolase to draw apoptosis codes in cancer." 03/01/2012 - "Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells." 11/01/2020 - "Poly(ADP-ribose) Glycohydrolase Inhibition Sequesters NAD+ to Potentiate the Metabolic Lethality of Alkylating Chemotherapy in IDH-Mutant Tumor Cells." 12/01/2010 - "A lot of effort has been put in by researchers and scientists over decades to find drugs helpful in the treatment of cancers for the benefit of patients--the latest being the Poly ADP-ribose polymerase (PARP) and the Poly ADP-ribose glycohydrolase (PARG) inhibitors. " 04/01/2012 - "Poly ADP-ribose polymerase (PARP) which is closely related to Poly ADP-ribose glycohydrolase (PARG) has already been thoroughly investigated in both experimental and clinical cancer trials compared to the latter. "
2.	Carcinogenesis 01/01/2019 - "Poly (ADP-ribosylation), as a key post-translational modification in BaP-induced carcinogenesis, is mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) in eukaryotic organisms. " 03/01/2021 - "Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis." 01/01/2019 - "In addition, we examined the role of a related regulatory protein of PARP-1, called Poly(ADP-ribose) glycohydrolase (PARG), in prostate carcinogenesis. " 10/01/2018 - "Poly (ADP-ribose) glycohydrolase silencing-mediated maintenance of H2A and downregulation of H2AK9me protect human bronchial epithelial cells from benzo(a)pyrene-induced carcinogenesis." 01/01/2015 - "Poly(ADP-ribose) glycohydrolase silencing down-regulates TCTP and Cofilin-1 associated with metastasis in benzo(a)pyrene carcinogenesis."
3.	Carcinoma (Carcinomatosis) 01/01/2019 - "In this study we investigated the effect of poly (ADP-ribose) glycohydrolase (PARG) deficiency on the ability of invasion in CT26 murine colon carcinoma cell and its possible mechanism. " 10/01/2012 - "Our aim was to investigate the influence of silencing poly-(ADP-ribose)glycohydrolase (PARG) in human colon carcinoma LoVo cells on the ability of human umbilical vein endothelial cell (HUVEC) migration, proliferation and its possible mechanisms. " 10/01/2012 - "Tannic acid, an inhibitor of poly(ADP-ribose) glycohydrolase, sensitizes ovarian carcinoma cells to cisplatin." 10/01/2012 - "TA was also found to enhance the toxicity of cisplatin in ovarian carcinoma cells associated with the inhibition of poly(ADP-ribose) glycohydrolase (PARG) expression, increase the accumulation of poly(ADP-ribose) (pADPr), following the release of apoptosis-inducing factor, and the activation of caspase-3. "
4.	Retinitis 01/01/2020 - "Additional studies showed the intraocular stimulation of mRNAs or proteins before MCMV retinitis development for two additional participants in parthanatos, polymer of ADP-ribose and poly (ADP-ribose) glycohydrolase. "
5.	Inflammation (Inflammations) 09/01/2013 - "Poly (ADP-ribose) glycohydrolase (PARG), which was discovered during studies on DNA damage study and in inflammation research, is an attractive target protein in current cancer research. "

Related Drugs and Biologics

1.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
2.	Proteins (Proteins, Gene)
3.	Poly Adenosine Diphosphate Ribose
4.	Enzymes
5.	Polymers
6.	Adenosine Diphosphate Ribose (ADP-Ribose)
7.	Benzo(a)pyrene
8.	Ethacridine (Ethacridine Lactate)
9.	Poly(ADP-ribose) Polymerase Inhibitors
10.	Apoptosis Inducing Factor

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics