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phosphoribosylamine-glycine ligase
Also Known As:
GAR synthetase; glycinamide ribonucleotide synthetase; phosphoribosyl-glycineamide synthetase; phosphoribosylglycinamide synthetase
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Ligases: 5553
Carbon-Nitrogen Ligases
phosphoribosylamine-glycine ligase: 5
Related Diseases
1.
Trisomy (Trisomies)
01/01/1984 - "
The enzymatic activity of phosphoribosylglycinamide synthetase (GARS) has been studied in several cases of partial monosomies and full and partial trisomies 21.
"
2.
Sarcoma (Soft Tissue Sarcoma)
05/01/1993 - "
Using this targeted cell fusion approach the nutritional markers, uridine monophosphate synthetase (UMPS), mapped onto human chromosome 3 (HSA3), phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase (GART) (HSA21), are reported to be located on sheep chromosome 1q; and phosphoribosyl pyrophosphate amidotransferase (PPAT) (HSA4) has been assigned to sheep chromosome 6. By isozyme analysis and Southern hybridization, transferrin (TF) and superoxide dismutase 1 (SOD1), both in the bovine syntenic group U10, were assigned to sheep chromosome 1q; adenylate kinase 1 (AK1), in the bovine syntenic group U16, to sheep chromosome 3p; lactate dehydrogenase B (LDHB) and phenylalanine hydroxylase (PAH) on bovine chromosome 5 (BTA5) to sheep chromosome 3q; phosphoglucomutase 2 (PGM2) (bovine syntenic group 15) to sheep chromosome 6 (t1q); avian myelocytomatosis viral oncogene homolog (MYC) and Moloney murine sarcoma viral oncogene homolog (MOS) (BTA 14) to sheep 9 (t2q); and glutathione reductase (GSR) (bovine syntenic group U14) to sheep 24 (t1p).
"
3.
Lymphoma (Lymphomas)
03/25/1989 - "
The enzyme purified from the murine lymphoma cell line L5178Y also catalyzes two other de novo purine biosynthetic activities, glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase.
"
4.
Down Syndrome (Down's Syndrome)
09/01/1986 - "
The levels of glycinamide ribonucleotide synthetase were monitored in four human fibroblast cell lines, two diploid, one monosomy 21 and one trisomy 21, from early passage number to senescence.
"
5.
Chromosome Deletion (Deletion, Chromosome)
01/01/1984 - "
The enzymatic activity of phosphoribosylglycinamide synthetase (GARS) has been studied in several cases of partial monosomies and full and partial trisomies 21.
"
Related Drugs and Biologics
1.
Ligases (Synthetase)
2.
Uridine Monophosphate (UMP)
3.
Transferrin (beta 2 Transferrin)
4.
Ribonucleotides
5.
Phosphoglucomutase
6.
Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)
7.
Isoenzymes
8.
Glutathione Reductase (Glutathione-Disulfide Reductase)
9.
Enzymes
10.
Amidophosphoribosyltransferase