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phosphoribosylaminoimidazole- succinocarboxamide synthetase

Also Known As:

SAICAR synthetase; SAICARs; aminoimidazole N-succinocarboxamide ribonucleotide synthetase; phosphoribosylaminoimidazole succinocarboxamide synthetase

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Nitrogen Ligases
      - Peptide Synthases: 10
        phosphoribosylaminoimidazole-succinocarboxamide synthetase: 7

Experts

1.	Chakravarthi, Balabhadrapatruni V S K: 3 articles (03/2020 - 09/2015)
2.	Varambally, Sooryanarayana: 3 articles (03/2020 - 09/2015)
3.	Agarwal, Sumit: 2 articles (03/2020 - 01/2017)
4.	Chandrashekar, Darshan S: 2 articles (03/2020 - 01/2017)
5.	Chinnaiyan, Arul M: 2 articles (01/2017 - 09/2015)
6.	Goswami, Moloy T: 2 articles (01/2017 - 09/2015)
7.	Palanisamy, Nallasivam: 2 articles (01/2017 - 09/2015)
8.	Pathi, Satya S: 2 articles (01/2017 - 09/2015)
9.	Dewulf, Joseph P: 1 article (01/2022)
10.	Marie, Sandrine: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an essential enzyme involved in de novo purine biosynthesis, is connected with formation of various tumors. " 01/01/1981 - "L-5178Y/AR tumor, small intestine, liver, and lung, which were more susceptible to damage by L-alanosine, showed high concentrations of the putative active antimetabolite of L-alanosine, "L-alanosyl-AICOR", and either high concentrations of SAICAR synthetase, which forms this conjugate or low specific activities of adenylosuccinate lyase, the enzyme believed to decompose it. "
2.	Carcinogenesis 08/10/2018 - "Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine biosynthesis, is associated with and involved in tumorigenesis. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2017 - "Next-generation sequencing, qRTPCR and immunoblot analysis revealed an elevated expression of a de novo purine biosynthetic gene, Phosphoribosylaminoimidazole Carboxylase, Phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS) in a progressive manner in prostate cancer. "
4.	Neoplasm Metastasis (Metastasis) 03/25/2020 - "We investigated the functional role of phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), a de novo purine biosynthetic enzyme involved in DNA synthesis, in CRC progression and metastasis by using cell and animal models. "
5.	Inborn Errors Metabolism (Inborn Errors of Metabolism) 01/01/2022 - "This review provides an overview of inborn errors of metabolism pertaining to purine synthesis in humans, including either phosphoribosylpyrophosphate synthetase (PRS) overactivity or deficiency, as well as adenylosuccinate lyase (ADSL), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), and adenylosuccinate synthetase (ADSS) deficiencies. "

Related Drugs and Biologics

1.	purine
2.	Enzymes
3.	phosphoribosylaminoimidazole carboxylase
4.	Adenylosuccinate Lyase
5.	Hydroxymethyl and Formyl Transferases
6.	Ribonucleotides
7.	Ligases (Synthetase)
8.	DNA (Deoxyribonucleic Acid)
9.	Antimetabolites
10.	Adenylosuccinate Synthase (Synthase, Adenylosuccinate)