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polyethylene glycol-glutaminase-asparaginase
covalent attachment of polyethylene glycol to nonessential amine groups of enzyme renders it nonimmunogenic for treatment of leukemia (EC 3.5.1.-)
Also Known As:
PEG-L-glutaminase-L-asparaginase; polyethyleneglycol-L-glutaminase-L-asparaginase; Glutaminase-asparaginase
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Amidohydrolases: 43
Asparaginase: 2285
polyethylene glycol-glutaminase-asparaginase: 7
Glutaminase: 838
polyethylene glycol-glutaminase-asparaginase: 7
Organic Chemicals: 133
Alcohols: 595
Glycols: 38
Ethylene Glycols: 8
Polyethylene Glycols: 3865
polyethylene glycol-glutaminase-asparaginase: 7
Macromolecular Substances: 97
Polymers: 13051
Polyethylene Glycols: 3865
polyethylene glycol-glutaminase-asparaginase: 7
Biomedical and Dental Materials
Polymers: 13051
Polyethylene Glycols: 3865
polyethylene glycol-glutaminase-asparaginase: 7
Technology, Industry, and Agriculture
Manufactured Materials
Biomedical and Dental Materials
Polymers: 13051
Polyethylene Glycols: 3865
polyethylene glycol-glutaminase-asparaginase: 7
Related Diseases
1.
Neoplasms (Cancer)
06/01/1981 - "
The effects of Acinetobacter glutaminase-asparaginase (AGA) on protein and energy requirements were evaluated in mice bearing Ehrlich ascites tumors.
"
10/01/1985 - "
Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase.
"
04/01/1981 - "
The combined actions of succinylated Acinetobacter glutaminase-asparaginase and 6-diazo-5-oxo-L-norleucine or Acivicin produced synergistic inhibition of nucleic acid synthesis in P388 tumor cells.
"
10/01/1985 - "
Forty-eight tumor-free mice and 32 mice bearing Ehrlich ascites tumor were randomized into 2 treatments, Acinetobacter glutaminase-asparaginase (AGA) (600 IU/kg/day for 7 days) and 0.9% NaCl controls, and into 2 or 3 isocaloric diets, normal protein (NP) (20 g protein/100 g diet), high protein (HP) (58 g protein/100 g diet), and zero protein (ZP) (tumor-free mice only).
"
2.
Ehrlich Tumor Carcinoma
06/01/1981 - "
Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminase-asparaginase.
"
10/01/1985 - "
Forty-eight tumor-free mice and 32 mice bearing Ehrlich ascites tumor were randomized into 2 treatments, Acinetobacter glutaminase-asparaginase (AGA) (600 IU/kg/day for 7 days) and 0.9% NaCl controls, and into 2 or 3 isocaloric diets, normal protein (NP) (20 g protein/100 g diet), high protein (HP) (58 g protein/100 g diet), and zero protein (ZP) (tumor-free mice only).
"
3.
Ascites
06/01/1981 - "
The effects of Acinetobacter glutaminase-asparaginase (AGA) on protein and energy requirements were evaluated in mice bearing Ehrlich ascites tumors.
"
10/01/1985 - "
Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase.
"
4.
Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
06/01/1981 - "
Amino acid utilization was evaluated in seven children with acute lymphocytic leukemia treated with succinylated Acinetobacter glutaminase-asparaginase.
"
5.
Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/01/1979 - "
Effect of succinylated Acinetobacter glutaminase-asparaginase treatment on an acute myeloid leukemia in the rat (BNML).
"
Related Drugs and Biologics
1.
Proteins (Proteins, Gene)
2.
Nitrogen
3.
GTP-Binding Proteins (G-Protein)
4.
Nucleic Acids
5.
Diazooxonorleucine
6.
Amino Acids
7.
Saline Solution
8.
acivicin (AT 125)
Related Therapies and Procedures
1.
High-Protein Diet