disaccharide tetrapeptide

isolated from E coli cell wall

Also Known As:

G(Anh)MTetra; N-acetylglucosaminyl-N-AcMu-Ala-gamma-Gln-mesodiaminopimelyl-Ala; N-acetylglucosaminyl-N-acetylmuraminyl-L-alanyl-gamma-D-glutaminylmesodiaminopimelyl-D-alanine; D-Alanine, N-(N-acetyl-4-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)muramoyl)-L-alanyl-D-gamma-glutamyl-meso-alpha,epsilon-diaminopimelyl-

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Haenssler, Eva: 1 article (08/2012)
2.	Isberg, Ralph R: 1 article (08/2012)
3.	Liu, Mingyu: 1 article (08/2012)
4.	Losick, Vicki P: 1 article (08/2012)
5.	Park, James T: 1 article (08/2012)
6.	Uehara, Tsuyoshi: 1 article (08/2012)

Related Diseases

1.	Whooping Cough (Pertussis) 05/01/1995 - "The respiratory epithelial pathology of pertussis (whooping cough) can be reproduced by tracheal cytotoxin (TCT), a disaccharide-tetrapeptide released by Bordetella pertussis. " 03/15/1993 - "Tracheal cytotoxin (TCT) is a disaccharide-tetrapeptide released by Bordetella pertussis, the causative agent of pertussis (whooping cough). " 07/01/1989 - "pertussis, is a disaccharide tetrapeptide subunit of peptidoglycan."
2.	Sepsis (Septicemia) 02/11/1994 - "These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis."
3.	Leukocytosis (Pleocytosis) 07/01/1993 - "The disaccharide-tetrapeptide, the major component of all gram-negative peptidoglycans, induced CSF leukocytosis and protein influx at doses as low as 0.4 microgram (0.42 nM). "
4.	Legionnaires' Disease (Legionnaire's Disease) 08/16/2012 - "Upon Legionella pneumophila infection of macrophages, the cytosolic PRR Nod1 recognizes anhydro-disaccharide-tetrapeptide (anhDSTP) generated by soluble lytic transglycosylase (SltL), the predominant bacterial peptidoglycan degrading enzyme, to activate NF-κB-dependent innate immune responses. "
5.	Hypersensitivity (Allergy) 07/01/1989 - "The T cell line specific for a bacterial cell wall peptidoglycan subunit, disaccharide tetrapeptide of diaminopimelic acid type, was examined for epitope specificity in elicitation of delayed-type hypersensitivity (DTH) in X-irradiated Lewis rats, using pairs of analogs different in optical configuration of the COOH-terminal amino acid. "

Related Drugs and Biologics

1.	Peptidoglycan (Murein)
2.	Cytotoxins (Cytolysins)
3.	Interleukin-1beta (Interleukin 1 beta)
4.	Cytokines
5.	Interleukin-6 (Interleukin 6)
6.	Proteins (Proteins, Gene)
7.	Enzymes
8.	Diaminopimelic Acid
9.	Epitopes
10.	Amino Acids