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9-anilinoacridine

Also Known As:

N-phenyl-9-acridinamine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        Amsacrine: 592
        9-anilinoacridine: 5

Experts

1.	Chen, Yi-Wei: 1 article (01/2012)
2.	Chien, Yueh: 1 article (01/2012)
3.	Chu, Pen-Yuan: 1 article (01/2012)
4.	Huang, Pin-I: 1 article (01/2012)
5.	Kao, Shou-Yen: 1 article (01/2012)
6.	Lee, Tsung-Heng: 1 article (01/2012)
7.	Lo, Jeng-Fan: 1 article (01/2012)
8.	Lo, Wen-Liang: 1 article (01/2012)
9.	Su, Tsann-Long: 1 article (01/2012)
10.	Tseng, Ling-Ming: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "BO-1051 is a new 9-anilinoacridine N-mustard-derivative anti-cancer drug that can effectively target a variety of cancer cell lines and inhibit tumorigenesis in vivo. " 04/01/2008 - "9-anilinoacridine contains a tricyclic and planar aromatic structure that enables DNA intercalation and inhibition of topoisomerase II. Two recently developed sulfide derivatives of 9-anilinoacridines, 2-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(2-hydroxyethyl)amino)ethan-1-ol (CK0402) and 3-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(3-hydroxypropyl)amino)propan-1-ol (CK0403), displayed potent cytotoxic activity in multiple cancer cell lines. "
2.	Leukemia 10/01/1982 - "A series of 9-anilinoacridine derivatives substituted in the anilino ring with a variety of phosphoramide and related substitutents has been prepared, and the antitumor activity has been evaluated both in vivo and in vitro against the L1210 or P-388 mouse leukemia systems. " 01/01/1992 - "We tested the cytotoxic and DNA-cleaving activities of two amsacrine analogues which were derivatives of 9-anilinoacridine (1'-methylcarbamate and 1'-benzenesulfonamide) against an amsacrine-resistant human leukemia cell line (HL-60/AMSA) whose resistance is due to an amsacrine-resistant topoisomerase II. Neither agent could overcome the amsacrine resistance of HL-60/AMSA. "
3.	Carcinogenesis 01/01/2012 - "BO-1051 is a new 9-anilinoacridine N-mustard-derivative anti-cancer drug that can effectively target a variety of cancer cell lines and inhibit tumorigenesis in vivo. "
4.	Malaria 03/16/2000 - "Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum."

Related Drugs and Biologics

1.	Type II DNA Topoisomerases (Topoisomerase II)
2.	DNA (Deoxyribonucleic Acid)
3.	Sulfides (Thioethers)
4.	Amsacrine (AMSA)
5.	BO-1051
6.	3- ((4- (4- (acridin- 9- ylamino)phenylthio)phenyl)(3- hydroxypropyl)amino)propan- 1- ol
7.	2- ((4- (4- (acridin- 9- ylamino)phenylthio)phenyl)(2- hydroxyethyl)amino)ethan- 1- ol
8.	phosphoramide