HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
changrolin
structure
Also Known As:
4-(3',5'-bis(N-pyrrolidinyl)methyl)-(4'-hydroxyanilino)quinazoline; Phenol, 2,6-bis(1-pyrrolidinylmethyl)-4-(4-quinazolinylamino)-
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
changrolin: 6
Related Diseases
1.
Cardiac Arrhythmias (Arrythmia)
01/01/1996 - "
Pharmacokinetic-pharmacodynamic analysis of changrolin in dogs with arrhythmia.
"
01/01/1996 - "
The pharmacokinetics and pharmacodynamics of changrolin (CRL) were studied in 7 dogs with arrhythmia induced by coronary artery ligature.
"
12/01/1983 - "
[Effects of intravenous infusion of changrolin on cardiac function of patients with arrhythmia].
"
09/01/1984 - "
[Anti-arrhythmic effect of changrolin combined with nicotinamide in experimental arrhythmia].
"
07/01/1979 - "
[Antiarrhythmic effect of 4-(3',5'-bis ((n-pyrrolidinyl) methyl)-4'-hydroxyanilino) quinazoline (changrolin) on aconitine-induced arrhythmia in rats (author's transl)].
"
2.
Tachycardia (Tachyarrhythmias)
10/01/1979 - "
Intravenous injections in dogs and rabbits caused (i) a mild tachycardia followed by bradycardia; (ii) a prolongation of P-R interval and a widening of QRS complex in the electrocardiogram; (iii) a gradual hypotehsion; (iv) a slight weakening of cardiac functions; and (v) only moderate influences on the hearts of dogs and rabbits when the rate of infusion was less than 1 mg/min. Changrolin could be well absorbed by oral administration.
"
09/01/1991 - "
The indole-derived compounds, which possessed side chains resembling those of changrolin (4-[3',5'-bis[(N-pyrrolidinyl)methyl]-4'-hydroxyaniline]-quinazoline) showed potent anti-arrhythmic activity by restoration of sinus rhythm from ouabain-induced tachycardia in guinea pigs.
"
3.
Bradycardia
10/01/1979 - "
Intravenous injections in dogs and rabbits caused (i) a mild tachycardia followed by bradycardia; (ii) a prolongation of P-R interval and a widening of QRS complex in the electrocardiogram; (iii) a gradual hypotehsion; (iv) a slight weakening of cardiac functions; and (v) only moderate influences on the hearts of dogs and rabbits when the rate of infusion was less than 1 mg/min. Changrolin could be well absorbed by oral administration.
"
Related Drugs and Biologics
1.
Quinazolines
2.
Anti-Arrhythmia Agents
3.
Ouabain (G Strophanthin)
4.
Niacinamide (Nicotinamide)
5.
Aconitine
6.
indole
Related Therapies and Procedures
1.
Ligation
2.
Intravenous Injections
3.
Intravenous Infusions
4.
Oral Administration