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avermectin B(1)a (C 076)

RN given refers to avermectin B(1)a; see also avermectins & demethylavermectins

Also Known As:

C 076; avermectin B1a; 5-O-demethylavermectin A1a; C-076

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Ivermectin: 3421
        avermectin B(1)a: 7

Experts

1.	Beppu, Kodai: 1 article (10/2021)
2.	Harada, Shuichi: 1 article (10/2021)
3.	Inoue, Koichi: 1 article (10/2021)
4.	Muguruma, Yoshio: 1 article (10/2021)
5.	Saito, Daichi: 1 article (10/2021)
6.	Takahashi, Miki: 1 article (10/2021)

Related Diseases

1.	Nematode Infections 08/01/1980 - "Efficacy of avermectin B1a for treatment of experimentally induced nematode infections in cattle." 08/01/1980 - "Two formulations of avermectin B1a, C-076 and MK-933, were examined for anthelmintic activity in two trials, each using 20 calves with experimentally produced nematode infections. "
2.	Body Weight (Weight, Body) 05/01/1984 - "Groups 2 to 4 were treated orally with avermectin B1a at dosage levels of 25, 50, and 100 micrograms/kg of body weight, respectively. " 07/01/1979 - "Avermectin B1a given at a dose level of 0.05 or 0.1 mg/kg of body weight caused rapid removal of Dirofilaria immitis microfilariae from the blood of dogs with heartworm infections. " 08/01/1980 - "In one trial, C-076 was given orally, and in the other trial, MK-933 was given by injection at dosages of 50, 100, and 200 micrograms/kg of body weight. "
3.	Neoplasms (Cancer) 07/27/2023 - "This study aimed to investigate the potential anti-cancer activities of avermectin B1a using the HCT-116 colon cancer cell line. " 07/27/2023 - "Avermectin B1a exhibits significant anti-cancer activity and enhances tubulin polymerization, suggesting that it can be used as a promising microtubule-targeting agent for the development of future anticancer drugs."
4.	Colonic Neoplasms (Colon Cancer) 07/27/2023 - "This study aimed to investigate the potential anti-cancer activities of avermectin B1a using the HCT-116 colon cancer cell line. "
5.	Paralysis (Palsy) 04/01/1984 - "Angiostrongylus cantonensis: paralysis due to avermectin B1a and ivermectin." 10/01/1980 - "Avermectin B1a (AVM) is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. " 04/01/1984 - "Paralysis due to avermectin B1a and ivermectin of Angiostrongylus cantonensis was compared to that of phenylephrine (an alpha-adrenergic agonist) and strychnine (a cholinergic inhibitor). "

Related Drugs and Biologics

1.	avermectin B(1)a (C 076)
2.	Ivermectin (Mectizan)
3.	Anthelmintics
4.	Cholinergic Agents (Cholinergics)
5.	Tubulin
6.	Strychnine
7.	Phenylephrine (Neo-Synephrine)
8.	Isotopes
9.	Antiparasitic Agents (Antiparasitics)
10.	Adrenergic alpha-Agonists (Adrenergic alpha-Agonist)