Ala(2)- enkephalinamide-Met (DAME)

synthetic enkephalin analog;

Also Known As:

DAME; DALA; enkephalinamide-Met, Ala(2)-; 2-Ala-Met-enkephalinamide; Ala(2)-Met(5)-enkephalinamide; D-Ala(2)-Leu(5)-enkephalinamide; D-Ala(2)-Met(5)-enkephalinamide; D-ala(2)-methionine-enkephalinamide; D-enkephalin; DALAMID; Met-enkephalinamide, Ala(2)-; dalamide; enkephalinamide, Ala(2), Met(5); enkephalinamide-Met, alanine(2)-; methionine-enkephalinamide, Ala(2)-

Networked: 99 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        Enkephalins: 1042
        Methionine Enkephalin: 610
        Ala(2)- enkephalinamide-Met: 99
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - Enkephalins: 1042
        Methionine Enkephalin: 610
        Ala(2)- enkephalinamide-Met: 99

Experts

1.	Charpentier, Danielle: 3 articles (08/2008 - 08/2006)
2.	Guertin, Louis: 3 articles (08/2008 - 08/2006)
3.	Tabet, Jean-Claude: 3 articles (08/2008 - 08/2006)
4.	Carmant, Lionel: 2 articles (11/2011 - 03/2007)
5.	Nguyen, Dang Khoa: 2 articles (11/2011 - 03/2007)
6.	Charbonneau, Nicolas: 2 articles (08/2008 - 08/2006)
7.	Gélinas, Michel: 2 articles (08/2008 - 08/2006)
8.	Larochelle, Daniel: 2 articles (08/2008 - 08/2006)
9.	Souliàres, Denis: 2 articles (08/2008 - 08/2008)
10.	del Vecchio, Pierre: 2 articles (08/2008 - 08/2006)

Related Diseases

1.	Shock 08/01/1986 - "It was found that rats receiving a daily injection with DALA (1.0 micrograms/side) into the VTA for 5 days demonstrated a significantly greater increase in DA metabolism in the nucleus accumbens and septum in response to foot shock (0.14 mA over 20 min) than did control rats. " 01/15/2021 - "On 15th April 2019, Parisians watched in shock as Notre-Dame de Paris, the iconic cathedral that has towered over their city for almost 900 years, was engulfed in flames. " 08/01/1986 - "Furthermore, the foot shock-induced behavioral sensitization to DALA was persistent for at least 10 days. " 08/01/1986 - "Conversely, rats receiving daily foot shock for 5 days had a significantly greater motor stimulant response to intra-VTA injection with DALA than sham-shocked rats. " 08/01/1986 - "Considering that the stimulant effect of both DALA and amphetamine is mediated, at least in part, via enhanced DA release, the present study determined whether or not cross-sensitization could be produced between intra-VTA injection with DALA and mild foot shock stress. "
2.	Drug Resistant Epilepsy 11/01/2011 - "VNS as practiced at Notre-Dame hospital is an efficacious and safe treatment for refractory epilepsy. " 11/01/2011 - "Retrospective study assessing the efficacy and tolerability of vagus nerve stimulation (VNS) for the treatment of refractory epilepsy at Notre-Dame Hospital. "
3.	COVID-19 01/01/2021 - "Participants included 349 individuals (age range = 26-89) from the Notre Dame Study of Health & Well-being who completed a 28-day, daily diary study at the beginning of the COVID-19 pandemic. " 09/01/2022 - "We used COVID-19 test results, daily health check reports, and contact tracing data to measure SARs and corresponding RRs among close contacts of index cases in a cohort of 12 960 young adults at the University of Notre Dame in Indiana for 103 days, from August 10 to November 20, 2020. "
4.	Rupture 09/26/2023 - "This prospective and interventional study involving 51 patients with chronic LCL rupture who had percutaneous LCL reconstruction using peroneus longus autograft was conducted between January 2021 and December 2022 in National Orthopaedic Hospital, Dala-Kano, Nigeria. "
5.	Human Influenza (Influenza) 01/01/2014 - "This study investigated the uptake, enablers, and barriers to annual influenza vaccination in medicine, nursing, and physiotherapy students at the University of Notre Dame Australia, Fremantle, using an online survey and semi-structured interviews. "

Related Drugs and Biologics

1.	salicylhydroxamic acid (SHAM)
2.	Amphetamine (Amfetamine)
3.	Peptides (Polypeptides)
4.	Morphine (MS Contin)
5.	Opioid Analgesics (Opioids)
6.	Naloxone (Narcan)
7.	Methadone (Dolophine)
8.	Etorphine (M99)
9.	Enzymes
10.	Enkephalins

Related Therapies and Procedures

1.	Hemiarthroplasty
2.	Radiotherapy
3.	Palliative Care (Palliative Therapy)
4.	Intravenous Administration
5.	Vagus Nerve Stimulation