di-N',N''-methylglyoxal bis(guanylhydrazone)

03/04/2016 - "In summary, TGBG has potential as novel anti-influenza therapeutic with a novel mechanism of action. "
03/04/2016 - "In addition, influenza-induced activation of the Akt signaling pathway was suppressed by TGBG in a dose-dependent manner. "
03/04/2016 - "1,3,4,6-tetra-O-galloyl-β-D-glucopyranoside (TGBG) from Euphorbia humifusa Willd showed broad-spectrum anti-influenza activity against two seasonal influenza A strains, A/California/07/2009 (H1N1) and A/Perth/16/2009 (H3N2), and seasonal influenza B strain B/Florida/04/2006. "
03/04/2016 - "Immunofluorescence assay demonstrated that TGBG significantly inhibits nuclear export of influenza nucleoproteins (NP) during the early stages of infection causing NP to accumulate in the nucleus. "
03/04/2016 - "We found that TGBG exhibits a novel antiviral mechanism that differs from the FDA-approved anti-influenza drugs oseltamivir which inhibits viral release, and amantadine which inhibits viral entry. "

03/04/2016 - "Immunofluorescence assay demonstrated that TGBG significantly inhibits nuclear export of influenza nucleoproteins (NP) during the early stages of infection causing NP to accumulate in the nucleus. "