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nucleoside triphosphate pyrophosphatase

Also Known As:

NTP pyrophosphohydrolase; ecto-nucleoside triphosphate pyrophosphohydrolase; nucleoside triphosphate pyrophosphohydrolase

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Pyrophosphatases: 171
        nucleoside triphosphate pyrophosphatase: 10

Experts

1.	Johnson, K: 2 articles (12/2001 - 02/2001)
2.	Terkeltaub, R: 2 articles (12/2001 - 02/2001)
3.	Ioerger, Thomas R: 1 article (06/2008)
4.	Javid-Majd, Farah: 1 article (06/2008)
5.	Sacchettini, James C: 1 article (06/2008)
6.	Yang, Dong: 1 article (06/2008)
7.	Goding, J: 1 article (12/2001)
8.	Pritzker, K: 1 article (12/2001)
9.	Boisvert, W A: 1 article (02/2001)
10.	Goldfine, I: 1 article (02/2001)

Related Diseases

1.	Chondrocalcinosis (Pseudogout) 09/01/1999 - "Increased nucleoside triphosphate pyrophosphohydrolase (NTPPPH) activity in chondrocytes is associated with cartilage matrix inorganic pyrophosphate (PPi) supersaturation in chondrocalcinosis. " 01/15/1994 - "The appearance of these pyrophosphates in the interstitial cartilagenous medium would be in large part due to the activity of an ectoenzyme, nucleoside triphosphate pyrophosphatase; increased activity of this ectoenzyme could be responsible for some chondrocalcinosis. " 12/01/2001 - "Aging associated elevations of cartilage extracellular inorganic pyrophosphate (PPi) and PPi-generating nucleoside triphosphate pyrophosphohydrolase (NTPPPH) are linked with degenerative arthritis in chondrocalcinosis. "
2.	Osteoarthritis 12/01/2001 - "Aging associated elevations of cartilage extracellular inorganic pyrophosphate (PPi) and PPi-generating nucleoside triphosphate pyrophosphohydrolase (NTPPPH) are linked with degenerative arthritis in chondrocalcinosis. " 04/01/1991 - "Free pyrophosphate and nucleoside triphosphate pyrophosphatase (NTPase) were estimated in synovial fluids from 50 subjects with normal knees and from 44 patients with rheumatoid arthritis, 61 with pyrophosphate arthropathy, and 59 with osteoarthritis. "
3.	Hyperostosis 06/01/1999 - "A naturally occurring nonsense truncation mutation of the inorganic pyrophosphate (PPi)-generating nucleoside triphosphate pyrophosphohydrolase (NTPPPH) PC-1 is associated with spinal and periarticular ligament hyperostosis and cartilage calcification in "tiptoe walking" (ttw) mice. "
4.	Tuberculosis (Tuberculoses) 06/01/2008 - "tuberculosis HisE provides insights into possible mechanisms of substrate binding and the diversity of the nucleoside-triphosphate pyrophosphatase superfamily."
5.	Osteosarcoma (Osteogenic Sarcoma) 02/01/1996 - "Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells."

Related Drugs and Biologics

1.	diphosphoric acid (pyrophosphoric acid)
2.	Nucleoside-Triphosphatase
3.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
4.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
5.	Diphosphates (Pyrophosphates)
6.	Calcium Pyrophosphate
7.	Alkaline Phosphatase
8.	Adenosine Triphosphate (ATP)