neurotoxic esterase

site of biochemical lesion in delayed neuronal degeneration produced by certain organophosphorus esters; insensitive to organophosphorus cpds such as paraoxon, but sensitive to mipafox

Also Known As:

Networked: 98 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fink, John K: 6 articles (01/2020 - 03/2008)
2.	Glynn, Paul: 6 articles (01/2020 - 09/2005)
3.	Richardson, Rudy J: 6 articles (01/2020 - 03/2008)
4.	Kretzschmar, Doris: 4 articles (10/2019 - 10/2014)
5.	Moretto, A: 4 articles (03/2007 - 02/2000)
6.	Chang, Ping-An: 4 articles (10/2006 - 04/2005)
7.	Wu, Yi-Jun: 4 articles (10/2006 - 04/2005)
8.	Hein, Nichole D: 3 articles (02/2015 - 07/2010)
9.	Vilanova, Eugenio: 3 articles (10/2014 - 04/2010)
10.	Lotti, M: 3 articles (03/2007 - 02/2000)

Related Diseases

1.	Polyneuropathies (Polyneuropathy) 07/01/1999 - "The delayed polyneuropathy sets in about 21 days after exposure, due to phosphorylation of neuropathy target esterase, and produces symmetrical motor weakness of peripheral muscles with a variable sensory component. " 12/12/1997 - "Neuropathy target esterase (NTE) is suggested to be the molecular target for the initiation of the organophosphorus induced delayed polyneuropathy (OPIDP). " 12/01/1995 - "The identification of neuropathy target esterase (NTE) as the site for initiation of organophosphorus-induced delayed polyneuropathy (OPIDP) has led to informative acute and chronic neurotoxicity tests (adopted by OECD and EPA), to structure/activity and in vitro/in vivo predictions, and to a sound basis for extrapolations to man. " 12/01/1995 - "Neuropathy target esterase (NTE) and organophosphorus-induced delayed polyneuropathy (OPIDP): recent advances." 08/01/1995 - "Neuropathy target esterase (NTE) is the proposed target site for the mechanism of initiation of the so-called organophosphorus-induced delayed polyneuropathy (OPIDP). "
2.	Neuroblastoma 07/12/2022 - "The Catalytic Domain of Neuropathy Target Esterase Influences Lipid Droplet Biogenesis and Lipid Metabolism in Human Neuroblastoma Cells." 11/18/2005 - "Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) cell line." 02/01/2023 - "The alteration of the expression level of neuropathy target esterase in human neuroblastoma SK-N-SH cells disrupts cellular phospholipids homeostasis." 04/01/2005 - "Inhibition of neuropathy target esterase expressing by antisense RNA does not affect neural differentiation in human neuroblastoma (SK-N-SH) cell line." 01/01/1994 - "Neuropathy target esterase inhibition by organophosphorus esters in human neuroblastoma cells."
3.	Ataxia (Dyssynergia) 07/01/1990 - "Indices of organophosphorus (OP)-induced delayed neuropathy (OPIDN) in the hen model have traditionally been restricted to the early inhibition of neuropathy target esterase (NTE) and ataxia with associated pathological changes in hind limb peripheral nerve which occur more than 7 days after OP exposure. " 10/13/1978 - "Doses given to hens caused high inhibition of brain neurotoxic esterase (NTE) but no ataxia. " 04/01/1993 - "Subsequent experiments in adult hens (the currently accepted animal model of choice for studies of OPIDN) showed that doses of CPS in excess of the LD50 in atropine-treated animals inhibited brain neurotoxic esterase (NTE) and produced mild to moderate ataxia. " 11/01/2001 - "The delayed neurotoxic potential of dichlorvos was assessed in terms of neuropathy target esterase (NTE) inhibition in the brain and the subsequent development of motor incoordination at 21 days post-exposure. " 06/01/1993 - "Relationship of neuropathy target esterase inhibition to neuropathology and ataxia in hens given organophosphorus esters."
4.	Poisoning 01/01/2001 - "Determinations of phenyl-valerate hydrolase activity to assess the severity of an acute organophosphorous compounds poisoning cannot be recommended, but phenyl-valerate hydrolase may have utility in worker surveillance." 11/01/1981 - "In tissue from a fatal human poisoning and from hens given 4-8 x unprotected LD50 AChE was highly inhibited and neurotoxic esterase uninhibited. " 09/01/1993 - "Quinalphos was slowly absorbed from the gastrointestinal tract, as indicated by the severity of the cholinergic symptoms and the inhibition of neuropathy target esterase, which reached its maximum 72 and 96 h after poisoning. " 07/01/2010 - "Poisoning includes acute cholinergic crisis as a result of AChE inhibition, intermediate syndrome (IMS) due to neuromuscular necrosis and organophosphate-induced delayed neuropathy (OPIDN) due to inhibition of neuropathy target esterase (NTE). " 08/01/1999 - "Neuropathy target esterase (NTE), the putative target enzyme for organophosphate induced delayed polyneuropathy (OPIDP), can be measured in lymphocytes but has rarely been assessed in acute human poisoning. "
5.	Pheochromocytoma 09/15/1998 - "This study compares two direct-acting neuropathy target esterase (NTE) inhibitors (mipafox and 2-octyl-4H-1,3,2-benzodioxophosphorin 2-oxide (OBDPO)), a metabolic precursor to an NTE inhibitor (tri-o-cresyl phosphate or TOCP) and a potent acetylcholinesterase inhibitor (chlorpyrifos oxon or CPO) for their effects on outgrowth of neurite-like and cell processes and on viability in differentiated cultured cells (rat adrenal pheochromocytoma (PC-12) and brain glial tumor (C6)). "

Related Drugs and Biologics

1.	Organophosphates
2.	phenyl di-n-pentylphosphinate
3.	Acetylcholinesterase
4.	Calcium
5.	mipafox
6.	Paraoxon (E600)
7.	methamidophos
8.	tri-o-cresyl phosphate (TOCP)
9.	Trichlorfon (Metrifonate)
10.	Isoflurophate (DFP)