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xanthotoxol

Also Known As:

8-hydroxypsoralen; 9-hydroxy-7H-furo(3,2-g)(1)benzopyran-7-one

Networked: 10 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        xanthotoxol: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        xanthotoxol: 10
  - 3-Ring Heterocyclic Compounds
    - Furocoumarins: 490
      - xanthotoxol: 10

Experts

1.	Hyun, Chang-Gu: 2 articles (05/2022 - 04/2022)
2.	Lee, Yeji: 2 articles (05/2022 - 04/2022)
3.	Florek-Łuszczki, Magdalena: 1 article (01/2021)
4.	Grabarska, Aneta: 1 article (01/2021)
5.	Plewa, Zbigniew: 1 article (01/2021)
6.	Wróblewska-Łuczka, Paula: 1 article (01/2021)
7.	Łuszczki, Jarogniew J: 1 article (01/2021)
8.	Acharya, Reetuparna: 1 article (10/2019)
9.	Bose, Pritha: 1 article (10/2019)
10.	Chacko, Shinu: 1 article (10/2019)

Related Diseases

1.	Brain Edema (Cerebral Edema) 05/01/2023 - "Xanthotoxol improved the neurological functions and reduced cerebral edema in ICH mice. " 05/01/2023 - "Xanthotoxol is reported to alleviate brain edema and inhibit inflammatory responses. " 07/01/2013 - "We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin. "
2.	Brain Ischemia (Cerebral Ischemia) 07/01/2013 - "These results, taken together with those of our previous study, suggest that the neuroprotection may be attributed to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia." 07/01/2013 - "The present study was designed to further determine the possible mechanisms of action of neuroprotective properties of xanthotoxol after cerebral ischemia. " 07/01/2013 - "Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia." 07/01/2013 - "We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin. "
3.	Reperfusion Injury 07/01/2013 - "We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin. "
4.	Neuroinflammatory Diseases 05/01/2023 - "Xanthotoxol ameliorates SBI post-ICH by suppressing microglia-mediated neuroinflammation and oxidative stress and enhancing microglial phagocytosis through inhibition of NF-κB signaling." 05/01/2023 - "Xanthotoxol alleviates secondary brain injury after intracerebral hemorrhage by inhibiting microglia-mediated neuroinflammation and oxidative stress."
5.	Melanoma (Melanoma, Malignant) 01/07/2021 - "Isobolographic analysis showed that for both melanoma cell lines, the combination of CDDP and osthole exerted synergistic and additive interactions, while the combination of CDDP and xanthotoxol exerted additive interactions. " 04/19/2022 - "The objectives of this study were to investigate the melanogenetic potential of the psoralen derivatives 5-hydroxypsoralen, 5-methoxypsoralen, 8-hydroxypsoralen, 8-methoxypsoralen, and 5,8-dimethoxypsoralen in B16F10 melanoma cells. " 01/07/2021 - "(2) An in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay on two human melanoma cell lines (FM55P and FM55M2) examined the antitumor properties of CDDP and five naturally occurring coumarins (osthole, xanthotoxin, xanthotoxol, isopimpinellin, and imperatorin). "

Related Drugs and Biologics

1.	E-Selectin
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	Methoxsalen (Oxsoralen)
4.	Ficusin (Psoralen)
5.	5-Methoxypsoralen
6.	isopimpinellin
7.	Neuroprotective Agents
8.	Lignans
9.	Furocoumarins (Furanocoumarins)
10.	Proteins (Proteins, Gene)