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2-tetradecylglycidic acid
structure
Also Known As:
2-tetradecylglycidic acid, (+-)-isomer; 2-tetradecylglycidic acid, (R)-isomer; 2-tetradecylglycidic acid, (S)-isomer; 2-tetradecyloxiranecarboxylic acid; McN-3802; palmoxiric acid
Networked:
4
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ethers: 242
Cyclic Ethers: 12
Epoxy Compounds: 689
2-tetradecylglycidic acid: 4
Lipids: 114793
Fatty Acids: 27405
2-tetradecylglycidic acid: 4
Related Diseases
1.
Hypertrophy
08/01/1999 - "
2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor.
"
10/01/1991 - "
To test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction.
"
08/01/1999 - "
This study tested the hypothesis that 2-tetradecylglycidic acid (TDGA), an oxirane carboxylate inhibitor of mitochondrial carnitine plamitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor system.
"
09/01/1993 - "
Studies from our laboratories have previously shown that 2-tetradecylglycidic acid, an inhibitor of carnitine palmitoyl transferase I, inhibits mitochondrial long-chain fatty acid oxidation and causes myocardial hypertrophy when given to rats by mouth for 7-28 days.
"
2.
Infarction (Infarctions)
10/01/1991 - "
To test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction.
"
3.
Body Weight (Weight, Body)
12/15/1984 - "
The effect of body weight and the fatty acid-oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in mouse heart.
"
Related Drugs and Biologics
1.
Carnitine (L-Carnitine)
2.
Fatty Acids (Saturated Fatty Acids)
3.
Transferases
4.
Ethylene Oxide (Oxirane)
5.
Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
6.
salicylhydroxamic acid (SHAM)