4,5'-dimethylangelicin

Also Known As:

4,8-dimethyl-2H-furo(2,3-h)-1-benzopyran-2- one

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        4,5'-dimethylangelicin: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        4,5'-dimethylangelicin: 4
  - 3-Ring Heterocyclic Compounds
    - Furocoumarins: 490
      - 4,5'-dimethylangelicin: 4

Related Diseases

1.	Ascites 07/01/1981 - "In short-term experiments such as the studies on macromolecular synthesis in Ehrlich ascites cells, in which the assay is performed that after irradiation, before DNA repair an intervene significantly, 4'-methylangelicin derivatives produced an inhibition of DNA and RNA synthesis 10 times higher than angelicin, the parent compound, and about 3.5 times higher than 4,5'-dimethylangelicin and psoralen, all assumed as reference compounds. "
2.	Phototoxic Dermatitis (Phototoxicity) 12/01/1983 - "The phototoxicity and mutagenicity of 4,5'-dimethylangelicin (Ang) were assessed in cultures of hamster cells and human skin fibroblasts after long-wave ultraviolet irradiation. " 12/01/1983 - "Phototoxicity and mutagenicity of 4,5'-dimethylangelicin and long-wave ultraviolet irradiation in Chinese hamster cells and human skin fibroblasts."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 02/01/1981 - "New monofunctional reagents for DNA as possible agents for the photochemotherapy of psoriasis: derivatives of 4,5'-dimethylangelicin." 02/01/1981 - "With the aim of obtaining new agents for the photochemotherapy of psoriasis, we have prepared monofunctional reagents for DNA by starting from 4,5'-dimethylangelicin (2), an angular furocoumarin, and introducing in a 4'-(hydroxymethyl) (3), 4'-(methoxymethyl) (4), or 4'-(aminomethyl) group (5), in way analogous to what other authors have done previously on trioxsalen, a DNA bifunctional reagent. "
4.	Photosensitivity Disorders (Photodermatitis) 03/01/1987 - "Compared to the linear derivative 8-methoxypsoralen (8-MOP) the angular structured furocoumarin 4,5'-dimethylangelicin (4,5'-DMA) causes smaller photosensitization effects (loss of viability, inhibition of phytohemagglutinin (PHA)-induced transformation rate and E-rosette formation of T-cells, respectively) on cultured human lymphocytes. "
5.	Erythema 07/01/1981 - "While, as already observed, angelicin and 4,5'-dimethylangelicin failed to induce erythema on guinea-pig skin, 4'-methylangelicin derivatives proved to be phototoxic; however in comparison with the cross-linking psoralen, much higher amounts of substance and radiation doses were required. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	RNA (Ribonucleic Acid)
3.	Ficusin (Psoralen)
4.	4'-methylangelicin
5.	angelicin
6.	Furocoumarins (Furanocoumarins)
7.	A-Form DNA (A-DNA)
8.	Trioxsalen (Trioxysalen)
9.	Phytohemagglutinins
10.	Methoxsalen (Oxsoralen)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)