bactericidal permeability increasing protein

from polymorphonuclear leukocytes; cationic bactericidal protein which increases envelope permeability of susceptible gram-negative bacteria; RefSeq NM_001725 (human)

Also Known As:

BPI protein; BPI protein, human; BPI protein, mouse; Bpi protein, rat; CAP 57 protein, human; antimicrobial cationic granule protein; bactericidal permeability-increasing protein, human; bactericidal permeability-increasing protein, mouse; bactericidal permeability-increasing protein, rat; polymorphonuclear leukocyte surface bactericidal permeability-increasing protein

Networked: 205 relevant articles (14 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - bactericidal permeability increasing protein: 205
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        bactericidal permeability increasing protein: 205
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - bactericidal permeability increasing protein: 205
  - Antimicrobial Cationic Peptides: 414
    - bactericidal permeability increasing protein: 205

Experts

1.	Gross, W L: 6 articles (02/2005 - 01/2000)
2.	Levy, Ofer: 5 articles (01/2015 - 01/2007)
3.	Csernok, E: 5 articles (02/2005 - 01/2000)
4.	Schultz, H: 5 articles (02/2005 - 01/2000)
5.	Schultz, Hendrik: 4 articles (09/2007 - 11/2004)
6.	Rigby, William F C: 3 articles (01/2021 - 01/2019)
7.	Skopelja-Gardner, Sladjana: 3 articles (01/2021 - 01/2019)
8.	Theprungsirikul, Jomkuan: 3 articles (01/2021 - 01/2019)
9.	Gessner, André: 3 articles (11/2020 - 01/2016)
10.	An, Yunqing: 3 articles (01/2020 - 02/2007)

Related Diseases

1.	Sepsis (Septicemia) 01/01/1995 - "Protective effects of a recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in an animal model of gram-negative sepsis." 12/01/1994 - "Protective effects of an N-terminal fragment of bactericidal/permeability-increasing protein in rodent models of gram-negative sepsis: role of bactericidal properties." 02/01/2009 - "Now in phase III clinical trials, rBPI(21), a recombinant N-terminal fragment of the bactericidal/permeability-increasing protein (BPI), is a promising drug to reduce lesions caused by meningococcal sepsis. " 09/16/2000 - "Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. " 12/01/2007 - "To evaluate the role of genetic polymorphisms of the bactericidal permeability increasing protein (BPI) in pediatric patients with sepsis. "
2.	Shock 02/01/1999 - "[Protective effects of bactericidal/permeability-increasing protein on the vital organ function after endotoxic shock in rats]." 11/01/1994 - "Protective effects of a recombinant N-terminal fragment of bactericidal/permeability increasing protein on endotoxic shock in conscious rabbits." 04/01/1995 - "Protection against endotoxic shock by bactericidal/permeability-increasing protein in rats." 01/01/2016 - "Halobacterial nano vesicles displaying murine bactericidal permeability-increasing protein rescue mice from lethal endotoxic shock." 08/01/1997 - "Recombinant N-terminal fragment of bactericidal/permeability increasing protein (rBPI21) prevents shock-induced microcirculatory alterations in the liver."
3.	Endotoxemia 01/01/2004 - "Protection from endotoxemia by adenoviral-mediated gene transfer of human bactericidal/permeability-increasing protein." 07/01/1995 - "We determined the effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein (rBPI23) on hemodynamic and renal sympathetic responses to lethal endotoxemia in unanesthetized rabbits. " 11/01/1993 - "Protective effect of a recombinant amino-terminal fragment of bactericidal/permeability-increasing protein in experimental endotoxemia." 05/01/1994 - "Bactericidal/permeability-increasing protein ameliorates acute lung injury in porcine endotoxemia." 06/15/1996 - "Release of bactericidal/permeability-increasing protein in experimental endotoxemia and clinical sepsis. "
4.	Otitis Media with Effusion 05/01/2000 - "In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. " 05/01/2000 - "Bactericidal/permeability-increasing protein prevents mucosal damage in an experimental rat model of chronic otitis media with effusion." 04/01/2001 - "Efficacy of bactericidal/permeability-increasing protein in experimental otitis media with effusion in rats: a new therapy for mucosal infections."
5.	Acute Lung Injury 05/01/1994 - "Bactericidal/permeability-increasing protein ameliorates acute lung injury in porcine endotoxemia." 08/01/2001 - "To investigate the role of recombinant bactericidal/permeability-increasing protein (rBPI21) in the attenuation of the sepsis syndrome and acute lung injury associated with lower limb ischemia-reperfusion (I/R) injury. " 08/01/2001 - "Bactericidal/permeability-increasing protein attenuates systemic inflammation and acute lung injury in porcine lower limb ischemia-reperfusion injury." 04/01/2005 - "[Protective effects of bactericidal/permeability increasing protein simulated peptide on murine acute lung injury induced by lipopolysaccharide]." 04/01/2005 - "To investigate the protective effects of bactericidal/permeability increasing protein simulated peptide (bactericidal neutralizing endotoxin protein, BNEP) on murine acute lung injury (ALI) induced by lipopolysaccharide (LPS). "

Related Drugs and Biologics

1.	Endotoxins
2.	Proteins (Proteins, Gene)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Autoantibodies
5.	Lipopolysaccharides
6.	Peptides (Polypeptides)
7.	Cytokines
8.	Interleukin-8 (Interleukin 8)
9.	Interleukins
10.	Immunoglobulin G (IgG)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation
3.	Surgical Amputation (Amputations)
4.	Perioperative Period
5.	Injections