pyro(l- alpha- aminoadipyl)- L- histidyl- L- thiazolidine- 4- carboxamide

RN given refers to cpd without isomeric designation

Also Known As:

(2S)-N-((2S)-1-((4S)-4-Carbamoyl-1,3-thiazolidin-3-yl)-3-(1H-imidazol-5-yl)-1-oxo-2-propanyl)-6-oxo-2-piperidinecarboxamide; MK 771; MK 771, (2S-(2R*(1R*(S*))))-isomer; MK 771, (2S-(2R*(R*(R*))))-isomer; MK-771; pyro-2-aminoadipylhistidylthiazolidine-4-carboxyamide; pyro-Aad-His-Tzl-NH2

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/1987 - "Preliminary studies on the effects of a TRH analog, MK-771, in an animal model of Alzheimer's disease." 01/01/1989 - "MK-771 and other TRH analogs may represent novel agents for improving memory deficits produced by cholinergic insufficiency in Alzheimer's disease."
2.	Shock 07/01/1984 - "TRH and MK-771 also produced marked increases in responding maintained by shock presentation at doses that did not alter or decreased food-maintained responding in the same subject. " 01/01/1984 - "Both TRH and MK-771 (1.0-30 mg/kg IM) produced dose-related decreases in punished responding maintained by food presentation and dose-related increases in punished responding maintained by shock termination. " 10/01/1983 - "TRH and MK 771 were shown to act within the brain to reverse endotoxic shock hypotension; at the doses used, the pressor effects of these two tripeptides were achieved through selectively different actions upon heart rate and pulse pressure. " 07/01/1984 - "TRH and MK-771 produced large, dose-related increases in responding maintained under the FR stimulus-shock termination schedule whereas these peptides produced smaller increases or did not affect responding under the FI schedule. " 07/01/1984 - "The effects of TRH (0.1-30 mg/kg) and an enzyme-resistant analogue, MK-771 (0.1-10 mg/kg), were characterized in squirrel monkeys on responding maintained in the presence of different visual stimuli by a multiple 3-min fixed-interval (FI), 30-response fixed-ratio (FR) schedule of stimulus-shock termination or by a multiple 5-min FI schedule of food or shock presentation. "
3.	Stupor 03/01/1978 - "TRH and MK-771 offset the narcosis induced by pentobarbital in mice, whereas the C-terminal free acid derived from TRH, melanostatin, somatostatin and pyroglutamyl-histidineamide have been found inactive. "
4.	Tremor (Tremors) 03/01/1978 - "Similarly, of these peptides only TRH and MK-771 induced a tremor of the forepaws in pentobarbital-anesthetized mice. "
5.	Tachycardia (Tachyarrhythmias) 07/01/1988 - "Propranolol, at a dose of 7 nmol, and methylatropine at a dose of 0.5 nmol, significantly inhibited the tachycardia produced by MK-771. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Enzymes
3.	Cholinergic Agents (Cholinergics)
4.	Thyrotropin-Releasing Hormone Receptors (Thyrotropin Releasing Hormone Receptor)
5.	Thyrotropin-Releasing Hormone (Protirelin)
6.	Somatostatin (Somatotropin Release-Inhibiting Factor)
7.	Propranolol (Inderal)
8.	Pentobarbital (Nembutal)
9.	MSH Release-Inhibiting Hormone (MIF-I)
10.	Methysergide (Sansert)