kynureninase

01/29/2023 - "Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis."
01/01/2023 - "Kynureninase (KYNU) is a potential prognostic marker for various tumor types. "
01/01/2022 - "We then explored the anti-tumor effect of Kynureninase (KYNU) modified CAR-T cells through catabolism o oncometabolites Kyn. "
04/01/1963 - "LIVER KYNURENINASE ACTIVITY OF TUMOR BEARING ANIMALS."
05/01/1959 - "[Kynureninase liver activity in tumor-bearing animals]."

12/01/2011 - "After having found no association with common polymorphisms, this study aimed to assess the role of 1 rare variant of KYNU, Arg188Gln, and kynureninase activity in relation to hypertension. "
01/01/2002 - "Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats."

01/01/2018 - "Here, we have collected the first evidence from a single study on the potential contributions to neuropathic pain development by enzymes in the kynurenine pathway [tryptophan 2,3-dioxygenase (TDO), indoleamine 2,3-dioxygenase (IDO1/2), kynurenine 3-monooxygenase (KMO); kynureninase, 3-hydroxyanthranilate-3,4-dioxygenase (HAOO)] at the spinal cord and dorsal root ganglia (DRG) levels. "

01/01/2021 - "Our previous study demonstrated that kynurenine 3-monooxygenase (KMO) and kynureninase were reduced in ischemia-reperfusion procedure and further decreased in rejection allografts among mismatched pig KTx. "

11/01/2021 - "Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation."
11/01/2021 - "The silencing of kynureninase in the cultured macrophages enhanced the expression of interleukin-6 and indoleamine 2,3-dioxygenase 1. Our study suggests the upregulation of the kynurenine pathway in macrophages in aortic atherosclerotic aneurysm. "